Evidence map›Paper›PMID 38746304›Full record

ArticlebioRxiv : the preprint server for biology2024

Evidence for multiple forms of heritable RNA silencing.

Mary S Chey, Pravrutha Raman, Farida Ettefa, Antony M Jose

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mary S CheyDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742.ORCID 0000-0003-0666-357X
Pravrutha RamanDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742.ORCID 0000-0002-7435-9425
Farida EttefaDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742.ORCID 0000-0003-0433-5951
Antony M JoseDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742.ORCID 0000-0003-1405-0618

Funding

Transgenerational gene silencing by extracellular RNAR01GM124356 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI JOSE, ANTONY MERLIN · 2018 to 2025
$2.8M
Movement of RNA between animal cellsR01GM111457 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI JOSE, ANTONY MERLIN · 2014 to 2018
$1.4M
NIGMS NIH HHS R01 GM111457NIGMS NIH HHS R01 GM124356
6 · The paper itself

Abstract

Heritable gene silencing has been proposed to rely on DNA methylation, histone modifications, and/or non-coding RNAs in different organisms. Here we demonstrate that multiple RNA-mediated mechanisms with distinct and easily detectable molecular signatures can underlie heritable silencing of the same open-reading frame in the nematode

Indexed as

epigeneticsgene regulationheredityoperonpoly-UG RNAstransgenerational gene silencing

Identifiers

PMID38746304
PMCPMC11092508

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.