Evidence map›Paper›PMID 38746260›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations.

Samantha G Malone, Christal N Davis, Zachary Piserchia, Michael R Setzer, Sylvanus Toikumo, Hang Zhou, Emma L Winterlind, Joel Gelernter, Amy Justice, Lorenzo Leggio and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Samantha G MaloneUniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology, Bethesda, MD 20814, United States.
Christal N DavisMental Illness Research, Education and Clinical Center, Crescenz VA Medical Center, Philadelphia, PA 19104, United States.ORCID 0000-0003-3974-5598
Zachary PiserchiaUniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology, Bethesda, MD 20814, United States.
Michael R SetzerUniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology, Bethesda, MD 20814, United States.
Sylvanus ToikumoMental Illness Research, Education and Clinical Center, Crescenz VA Medical Center, Philadelphia, PA 19104, United States.
Hang ZhouVeterans Affairs Connecticut Healthcare System, West Haven, CT 06516, United States.
Emma L WinterlindUniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology, Bethesda, MD 20814, United States.
Joel GelernterVeterans Affairs Connecticut Healthcare System, West Haven, CT 06516, United States.ORCID 0000-0002-4067-1859
Amy JusticeVeterans Affairs Connecticut Healthcare System, West Haven, CT 06516, United States.
Lorenzo LeggioClinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Baltimore, MD 21224, United States.
Christopher T RentschDepartment of Medicine, Yale University School of Medicine, New Haven, CT 06510, United States.ORCID 0000-0002-1408-7907
Henry R KranzlerMental Illness Research, Education and Clinical Center, Crescenz VA Medical Center, Philadelphia, PA 19104, United States.
Joshua C GrayUniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology, Bethesda, MD 20814, United States.

Funding

Leveraging GWAS Findings to Map Variants and Identify Novel Effector Genes for Alcohol-Related TraitsR01AA030056 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI Struan F A Grant, MATTHEW S KAYSER · 2023 to 2026
$2.5M
Leveraging genetic and electronic health records data to identify novel targets and drugs for treating alcoholR01AA030041 · NIAAA · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI GRAY, JOSHUA CHARLES · 2022 to 2025
$2.3M
NIAAA NIH HHS R01 AA030041NIAAA NIH HHS R01 AA030056
6 · The paper itself

Abstract

Despite neurobiological overlap, alcohol use disorder (AUD) and body mass index (BMI) show minimal genetic correlation (r

Identifiers

PMID38746260
PMCPMC11092735

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.