Evidence map›Paper›PMID 38746241›Full record

ArticlebioRxiv : the preprint server for biology2025

High-throughput crystallographic fragment screening of Zika virus NS3 Helicase.

Andre Schutzer Godoy, Charline Giroud, Nathalya C M R Mesquita, Gabriela Dias Noske, Victor Oliveira Gawriljuk, Ryan M Lithgo, Blake H Balcomb, Jasmin Cara Aschenbrenner, Charles W E Tomlinson, Max Winokan and 13 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Andre Schutzer GodoySão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100 - Jardim Santa Angelina, São Carlos, 13563-120, Brazil.ORCID 0000-0002-0613-9164
Charline GiroudResearch Complex at Harwell, Harwell Science and Innovation Campus, Fermi Ave, Didcot, OX11 0FA, UK.
Nathalya C M R MesquitaSão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100 - Jardim Santa Angelina, São Carlos, 13563-120, Brazil.
Gabriela Dias NoskeSão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100 - Jardim Santa Angelina, São Carlos, 13563-120, Brazil.ORCID 0000-0002-6498-6521
Victor Oliveira GawriljukSão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100 - Jardim Santa Angelina, São Carlos, 13563-120, Brazil.ORCID 0000-0001-5965-9326
Ryan M LithgoDiamond Light Source, Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, UK.ORCID 0000-0002-4706-9916
Blake H BalcombDiamond Light Source, Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, UK.ORCID 0000-0001-7599-8467
Jasmin Cara AschenbrennerDiamond Light Source, Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, UK.ORCID 0000-0002-4318-0481
Charles W E TomlinsonDiamond Light Source, Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, UK.ORCID 0000-0002-1845-6028
Max WinokanDiamond Light Source, Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, UK.ORCID 0000-0002-1318-4422
Jenke ScheenOpen Molecular Sciences Foundation, Davis, CA 95618, USA.ORCID 0000-0001-9781-0445
Hugo MacDermott-OpeskinOpen Molecular Sciences Foundation, Davis, CA 95618, USA.
Peter George MarplesDiamond Light Source, Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, UK.ORCID 0000-0002-8787-7969
Anu V ChandranDiamond Light Source, Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, UK.ORCID 0000-0001-9942-2614
Xiaomin NiDiamond Light Source, Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, UK.ORCID 0000-0002-7769-8297
Warren ThompsonDiamond Light Source, Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, UK.ORCID 0000-0003-1474-7810
Michael FairheadCentre for Medicines Discovery, Nuffield Department of Medicine Research Building, Old Road Campus, Headington, Oxford, OX3 7FZ, UK.ORCID 0000-0001-5361-3933
Daren FearonDiamond Light Source, Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, UK.ORCID 0000-0003-3529-7863
Lizbé KoekemoerCentre for Medicines Discovery, Nuffield Department of Medicine Research Building, Old Road Campus, Headington, Oxford, OX3 7FZ, UK.ORCID 0000-0001-9226-9127
Mary-Ann Elvina XavierDiamond Light Source, Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, UK.ORCID 0000-0002-1709-9479
Martin WalshDiamond Light Source, Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, UK.ORCID 0000-0001-5683-1151
Glaucius OlivaSão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100 - Jardim Santa Angelina, São Carlos, 13563-120, Brazil.ORCID 0000-0003-2719-0302
Frank von DelftDiamond Light Source, Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, UK.ORCID 0000-0003-0378-0017

Funding

Target enablementU19AI171399 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI CHODERA, JOHN DAMON, LEE, ALPHA ALBERT · 2022 to 2025
$89.8M
NIAID NIH HHS U19 AI171399
6 · The paper itself

Abstract

The Zika virus (ZIKV), discovered in Africa in 1947, swiftly spread across continents, causing significant concern due to its recent association with microcephaly in newborns and Guillain-Barré syndrome in adults. Despite a decrease in prevalence, the potential for a resurgence remains, necessitating urgent therapeutic interventions. Like other flaviviruses, ZIKV presents promising drug targets within its replication machinery, notably the NS3 helicase (NS3

Indexed as

flavivirusfragment-screeninghelicaseNS3Zika virus

Identifiers

PMID38746241
PMCPMC11092484

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.