Evidence map›Paper›PMID 38746172›Full record

ArticleResearch square2024

Persistent Impact of Antenatal Maternal Anaemia on Child Brain Structure at 6-7 Years of Age: A South African Child Health Study.

Jessica E Ringshaw, Chanelle Hendrikse, Catherine J Wedderburn, Layla E Bradford, Simone R Williams, Charmaine N Nyakonda, Sivenesi Subramoney, Marilyn T Lake, Tiffany Burd, Nadia Hoffman and 7 more

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In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Jessica E RingshawDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and Neuroscience Institute, University of Cape Town.
Chanelle HendrikseDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and Neuroscience Institute, University of Cape Town.
Catherine J WedderburnDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and Neuroscience Institute, University of Cape Town.
Layla E BradfordDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and Neuroscience Institute, University of Cape Town.
Simone R WilliamsDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and Neuroscience Institute, University of Cape Town.
Charmaine N NyakondaDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and Neuroscience Institute, University of Cape Town.
Sivenesi SubramoneyDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town.
Marilyn T LakeDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town.
Tiffany BurdDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town.
Nadia HoffmanDepartment of Psychiatry & Mental Health, University of Cape Town.
Annerine RoosSouth African Medical Research Council (SAMRC), Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute.
Katherine L NarrDepartment of Neurology, University of California Los Angeles.
Shantanu H JoshiDepartment of Neurology, University of California Los Angeles.
Steven C R WilliamsCentre for Neuroimaging Sciences, Department of Neuroimaging, Kings College London.
Heather J ZarDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town.
Dan J SteinSouth African Medical Research Council (SAMRC), Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute.
Kirsten A DonaldDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and Neuroscience Institute, University of Cape Town.

Funding

Tracking and Prediction of Early Brain-Face Biomarkers of Prenatal Alcohol Exposure from Neonates to ChildrenR01AA026834 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Kirsty Donald, Shantanu H. Joshi · 2018 to 2026
$3.8M
NIAAA NIH HHS R01 AA026834Wellcome Trust
6 · The paper itself

Abstract

Background: The study aim was to determine whether associations of antenatal maternal anaemia with smaller corpus callosum, putamen, and caudate nucleus volumes previously described in children at age 2-3 years persist to age 6-7 years in the Drakenstein Child Health Study (DCHS). Methods: This neuroimaging sub-study was nested within the DCHS, a South African population-based birth cohort. Pregnant women were enrolled (2012-2015) and mother-child dyads were followed prospectively. A sub-group of children had magnetic resonance imaging at 6-7 years of age (2018-2022). Mothers had haemoglobin measurements during pregnancy and a proportion of children were tested postnatally. Maternal anaemia (haemoglobin<11g/dL) and child anaemia were classified using WHO and local guidelines. Linear modeling was used to investigate associations between antenatal maternal anaemia status, maternal haemoglobin concentrations, and regional child brain volumes. Models included potential confounders and were conducted with and without child anaemia to assess the relative roles of antenatal versus postnatal anaemia. Results: Overall, 157 children ( Conclusions: Associations between maternal anaemia and regional child brain volumes previously reported at 2-3 years of age were consistent and persisted to 6-7 years of age. Findings support the importance of optimizing antenatal maternal health and reinforce these brain regions as a future research focus on intervention outcomes.

Indexed as

antenatal maternal anaemiachild brain structuremagnetic resonance imagingneurodevelopmentNeuroimaging

Identifiers

PMID38746172
PMCPMC11092825

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.