Evidence map›Paper›PMID 38746149›Full record

ArticlebioRxiv : the preprint server for biology2024

Venom-inspired somatostatin receptor 4 (SSTR4) agonists as new drug leads for peripheral pain conditions.

Walden E Bjørn-Yoshimoto, Iris Bea L Ramiro, Thomas Lund Koch, Ebbe Engholm, Ho Yan Yeung, Kasper K Sørensen, Carolyn M Goddard, Kathrine L Jensen, Nicholas A Smith, Laurent F Martin and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Walden E Bjørn-YoshimotoORCID 0000-0003-1019-9239
Iris Bea L RamiroORCID 0000-0003-3971-3107
Thomas Lund KochORCID 0000-0002-8489-0375
Ebbe Engholm
Ho Yan YeungORCID 0000-0003-3087-238X
Kasper K Sørensen
Carolyn M Goddard
Kathrine L Jensen
Nicholas A SmithORCID 0000-0001-8894-4249
Laurent F MartinORCID 0000-0001-7358-5335
Brian J Smith
Kenneth L Madsen
Knud J JensenORCID 0000-0003-3525-5452
Amol Patwardhan
Helena Safavi-HemamiORCID 0000-0002-1984-2721

Funding

Validation of Spinal Neurotensin Receptor 2 as an Analgesic TargetR01NS116694 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PATWARDHAN, AMOL M · 2020 to 2025
$2.0M
NINDS NIH HHS R01 NS116694
6 · The paper itself

Abstract

Persistent pain affects one in five people worldwide, often with severely debilitating consequences. Current treatment options, which can be effective for mild or acute pain, are ill-suited for moderate-to-severe persistent pain, resulting in an urgent need for new therapeutics. In recent years, the somatostatin receptor 4 (SSTR One Sentence Summary: Venom peptides from predatory marine mollusks provide new leads for treating peripheral pain conditions through a non-opioid target.

Identifiers

PMID38746149
PMCPMC11092515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.