Evidence map›Paper›PMID 38745984›Full record

ArticleJournal of biomedical optics2024

Generalized 3D registration algorithm for enhancing retinal optical coherence tomography images.

Tiffany Tse, Yudan Chen, Mahsa Siadati, Yusi Miao, Jun Song, Da Ma, Zaid Mammo, Myeong Jin Ju

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tiffany TseThe University of British Columbia, School of Biomedical Engineering, Faculty of Medicine and Applied Science, Vancouver, British Columbia, Canada.ORCID 0009-0005-9895-8165
Yudan ChenThe University of British Columbia, School of Biomedical Engineering, Faculty of Medicine and Applied Science, Vancouver, British Columbia, Canada.
Mahsa SiadatiThe University of British Columbia, School of Biomedical Engineering, Faculty of Medicine and Applied Science, Vancouver, British Columbia, Canada.
Yusi MiaoThe University of British Columbia, Department of Ophthalmology and Visual Sciences, Faculty of Medicine, Vancouver, British Columbia, Canada.
Jun SongThe University of British Columbia, School of Biomedical Engineering, Faculty of Medicine and Applied Science, Vancouver, British Columbia, Canada.ORCID 0009-0000-5875-484X
Da MaWake Forest University, School of Medicine, Winston-Salem, North Carolina, United States.
Zaid MammoThe University of British Columbia, Department of Ophthalmology and Visual Sciences, Faculty of Medicine, Vancouver, British Columbia, Canada.
Myeong Jin JuThe University of British Columbia, School of Biomedical Engineering, Faculty of Medicine and Applied Science, Vancouver, British Columbia, Canada.ORCID 0000-0002-4907-3732

Funding

CIHR
6 · The paper itself

Abstract

Significance: Optical coherence tomography (OCT) has emerged as the standard of care for diagnosing and monitoring the treatment of various ocular disorders due to its noninvasive nature and Aim: We aim to generate an OCT volume free of motion artifacts using a system-agnostic registration algorithm that is independent of system specifications or protocol. Approach: We developed a B-scan registration algorithm that removes motion and corrects for both translational eye movements and rotational angle differences between volumes. Tests were carried out on various datasets obtained from two different types of custom-built OCT systems and one commercially available system to determine the reliability of the proposed algorithm. Additionally, different system specifications were used, with variations in axial resolution, lateral resolution, signal-to-noise ratio, and real-time motion tracking. The accuracy of this method has further been evaluated through mean squared error (MSE) and multiscale structural similarity index measure (MS-SSIM). Results: The results demonstrate improvements in the overall contrast of the images, facilitating detailed visualization of retinal vasculatures in both superficial and deep vasculature plexus. Finer features of the inner and outer retina, such as photoreceptors and other pathology-specific features, are discernible after multivolume registration and averaging. Quantitative analyses affirm that increasing the number of averaged registered volumes will decrease MSE and increase MS-SSIM as compared to the reference volume. Conclusions: The multivolume registered data obtained from this algorithm offers significantly improved visualization of the retinal microvascular network as well as retinal morphological features. Furthermore, we have validated that the versatility of our methodology extends beyond specific OCT modalities, thereby enhancing the clinical utility of OCT for the diagnosis and monitoring of ocular pathologies.

Indexed as

AlgorithmsImaging, Three-DimensionalRetinaTomography, Optical CoherenceArtifactsHumansReproducibility of ResultsSignal-To-Noise Ratioangiographyimage processingimage registrationophthalmologyoptical coherence tomographyretinal imaging

Identifiers

PMID38745984
PMCPMC11091473

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.