ArticleFrontiers in endocrinology2024
Diabetes mellitus, systemic inflammation and overactive bladder.
Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Associations of estimated glucose disposal rate and overactive bladder and the potential mediating role of systemic inflammation: NHANES 2005-2018.Diabetology & metabolic syndrome · 2026Article
- Article
- Therapeutic Potential of Mitochondrial Transplantation with Focus on DBD.International journal of molecular sciences · 2026Review
- Article
- The Interaction Between Mitophagy Dysregulation and the Diabetic Bladder Microenvironment.Journal of diabetes · 2026Review
- Association between dietary intake of fatty acids, central obesity, and OAB: insights from a prospective cohort for weight management and dietary prevention.Therapeutic advances in endocrinology and metabolism · 2026Article
- Periodontitis as a potential amplifier of diabetes-related genitourinary complications: evidence gradients and mechanistic insights into the inflammation-microvascular injury axis.Frontiers in cellular and infection microbiology · 2026Review
- Association between cardiometabolic index and overactive bladder in adults: Evidence from the National Health and Nutrition Examination Survey 2011-2018.Asian journal of urology · 2026Article
- Exploring the association between the ZJU index and overactive bladder: a cross-sectional study based on NHANES 2011-2018.Translational andrology and urology · 2025Article
- Bladder Dysfunction in Sickle Cell Disease Is Associated with Inflammation and Oxidative Stress.International journal of molecular sciences · 2025Article
- A multidimensional analysis-based risk prediction model for stress urinary incontinence in middle-aged and elderly women.BMC women's health · 2025Article
- Relationship between metabolic syndrome and overactive bladder: insights from the NHANES and Mendelian randomization study.Diabetology & metabolic syndrome · 2025Article
- Association of the Triglyceride Glucose Index with Symptoms of Overactive Bladder in American Female Adults: A Cross-Sectional Study.International urogynecology journal · 2025Article
- The association between the systemic inflammation response index and overactive bladder: a cross-sectional study.European journal of medical research · 2025Article
- Predicting overactive bladder from inflammatory markers: A machine learning approach using NHANES 2005-2020.Biomolecules & biomedicine · 2025Article
- Application of the C-reactive protein-triglyceride glucose index in predicting the risk of new-onset diabetes in the general population aged 45 years and older: a national prospective cohort study.BMC endocrine disorders · 2025Article
- Association of overactive bladder with all-cause and cardiovascular mortality in women: A propensity-matched NHANES study.BJUI compass · 2025Article
- Role and mechanism of Roux-en-Y gastric bypass in the treatment of diabetic urinary bladder hyperactivity by reducing TRPV1 and P2X3.World journal of diabetes · 2025Article
- The association between serum albumin-globulin ratio and overactive bladder in American adults: a cross-sectional study.European journal of medical research · 2025Article
- The Sex-Dependent Ameliorative Effect of Intermittent Fasting on Urinary System Functions in Genetic Absence Epileptic Rats.Biology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Background: Increasing evidence emphasizes the potential relationship between diabetes and OAB (overactive bladder). However, large population epidemiology is still lacking. Methods: This cross-sectional study included six cycle NHANES surveys, with a total of 23863 participants. Logistic regression models were constructed to analyze the association between diabetes mellitus, diabetes-related markers, and inflammatory biomarkers with OAB. Restricted cubic splines were used to analyze the non-linear associations. Mediating analysis was performed to test the effect of inflammatory biomarkers on the relationship between diabetes-related markers and OAB. Finally, machine learning models were applied to predict the relative importance and construct the best-fit model. Results: Diabetes mellitus participants' OAB prevalence increased by 77% compared with non-diabetes. As the quartiles of diabetes-related markers increased, the odds of OAB monotonically increased in three models (all p for trend < 0.001). Glycohemoglobin exhibited a linear association with OAB (p for nonlinearity > 0.05). White blood cells significantly mediated the associations between diabetes-related markers (glycohemoglobin, fasting glucose, and insulin) with OAB, and the proportions were 7.23%, 8.08%, and 17.74%, respectively (all p < 0.0001). Neutrophils partly mediated the correlation between (glycohemoglobin, fasting glucose, and insulin) and OAB at 6.58%, 9.64%, and 17.93%, respectively (all p < 0.0001). Machine learning of the XGBoost model constructs the best fit model, and XGBoost predicts glycohemoglobin is the most important indicator on OAB. Conclusion: Our research revealed diabetes mellitus and diabetes-related markers were remarkably associated with OAB, and systemic inflammation was an important mediator of this association.
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