Evidence map›Paper›PMID 38745825›Full record

ArticleJournal of the Endocrine Society2024

Functional Analysis of a Novel

Shuntaro Morikawa, Hui Ling Ko, Ee Chee Ren, Kazuya Hara, Naoya Kaneko, Nozomi Hishimura, Akie Nakamura, Atsushi Manabe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuntaro MorikawaDepartment of Pediatrics, Hokkaido University Hospital, Sapporo, 060-8648, Japan.ORCID https://orcid.org/0000-0001-5547-9491
Hui Ling KoSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore.ORCID https://orcid.org/0000-0002-7835-8120
Ee Chee RenSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore.ORCID https://orcid.org/0000-0001-5039-2207
Kazuya HaraDepartment of Pediatrics, Chitose City Hospital, Chitose, 066-0033, Japan.
Naoya KanekoDepartment of Pediatrics, Hokkaido University Hospital, Sapporo, 060-8648, Japan.
Nozomi HishimuraDepartment of Pediatrics, Hokkaido University Hospital, Sapporo, 060-8648, Japan.
Akie NakamuraDepartment of Pediatrics, Hokkaido University Hospital, Sapporo, 060-8648, Japan.
Atsushi ManabeDepartment of Pediatrics, Hokkaido University Hospital, Sapporo, 060-8648, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: HNF4A-maturity-onset diabetes of the young (MODY1) is a relatively rare subtype of monogenic diabetes caused by loss of function of the Objective: In this study, we analyzed the functional consequence of the Methods: We investigated the case of a 12-year-old Japanese girl who developed diabetes at age 11 years. Genetic sequencing detected a novel heterozygous missense Results: Although the WT HNF4α isoforms (HNF4α2, HNF4α3, HNF4α8, HNF4α9) enhanced the Conclusion: We report the clinical course of a patient with HNF4A-MODY and the functional analysis of novel

Indexed as

diabetesHNF4A-MODYHNF4αisoformMODY1transcription

Identifiers

PMID38745825
PMCPMC11091833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.