Evidence map›Paper›PMID 38745806›Full record

ArticleCureus2024

Tonsillar Metastasis of Hepatocellular Carcinoma: A Case Report and Review of the Literature.

Chalothorn Wannaphut, Toshiaki Takahashi, Sharina Macapagal, Manasawee Tanariyakul, Sorawit Ongsupankul, Thanaboon Yinadsawaphan, Yoshito Nishimura, Jared Acoba

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chalothorn WannaphutInternal Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, USA.
Toshiaki TakahashiInternal Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, USA.
Sharina MacapagalInternal Medicine, University of Hawaii, Honolulu, USA.
Manasawee TanariyakulInternal Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, USA.
Sorawit OngsupankulInternal Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, USA.
Thanaboon YinadsawaphanInternal Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, USA.
Yoshito NishimuraInternal Medicine, University of Hawaii, Honolulu, USA.
Jared AcobaHematology and Oncology, The Queen's Medical Center, Honolulu, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 63-year-old male with stage IV hepatocellular carcinoma (HCC), accompanied by lung and adrenal metastases, presented with oral bleeding. Physical examination disclosed bleeding from the tonsillar mass. A head and neck computed tomography identified a 2.4 cm enhancing lesion in the right anterior ethmoidal sinus, extending to the nasal region and medial orbit. Tonsillar mass biopsy confirmed HCC metastasis, immunopositive for Hepatocyte Paraffin 1 (HepPar1) and Arginase. He was treated with local radiotherapy (30 fractions). The unique presentation of severe bleeding from a tonsillar biopsy-proven HCC metastatic lesion underscores the rarity of head and neck involvement. Extrahepatic metastasis, particularly to the head and neck area likely due to hematogenous spread, may be a major independent predictor of poor outcomes in HCC patients. Local radiotherapy to achieve local hemostasis and reduce tumor bulk should be considered. In patients with known HCC having new oropharyngeal symptoms, HCC metastasis should be considered for a timely diagnosis. Despite its rarity, this manifestation signifies an unfavorable prognosis, reinforcing the imperative for a multidisciplinary approach to enhance therapeutic outcomes in these complex scenarios.

Indexed as

extrahepatic metastasishead and neck neoplasmshepatocellular carcinomaoral bleedingtonsillar metastasis

Identifiers

PMID38745806
PMCPMC11093587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.