Evidence map›Paper›PMID 38745701›Full record

ArticleArXiv2024

3D MR Fingerprinting for Dynamic Contrast-Enhanced Imaging of Whole Mouse Brain.

Yuran Zhu, Guanhua Wang, Yuning Gu, Walter Zhao, Jiahao Lu, Junqing Zhu, Christina J MacAskill, Andrew Dupuis, Mark A Griswold, Dan Ma and 2 more

Abstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yuran ZhuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Guanhua WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Yuning GuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Walter ZhaoDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Jiahao LuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Junqing ZhuDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
Christina J MacAskillDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Andrew DupuisDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Mark A GriswoldDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Dan MaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Chris A FlaskDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Xin YuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Interdisciplinary Biomedical Imaging Training ProgramT32EB007509 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI DAVID Lynn WILSON, Xin Yu · 2007 to 2026
$5.6M
Clinical and Translational Science Collaborative of ClevelandTL1TR000441 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$2.8M
AQP4 and glymphatic function in post-stroke recoveryR01NS124206 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI Christopher A Flask, Xin Yu · 2022 to 2026
$2.8M
NCATS NIH HHS TL1 TR000441NIBIB NIH HHS T32 EB007509NIGMS NIH HHS T32 GM007250NINDS NIH HHS R01 NS124206
6 · The paper itself

Abstract

Purpose: Quantitative MRI enables direct quantification of contrast agent concentrations in contrast-enhanced scans. However, the lengthy scan times required by conventional methods are inadequate for tracking contrast agent transport dynamically in mouse brain. We developed a 3D MR fingerprinting (MRF) method for simultaneous T Method: We designed a 3D MRF sequence with variable acquisition segment lengths and magnetization preparations on a 9.4T preclinical MRI scanner. Model-based reconstruction approaches were employed to improve the accuracy and speed of MRF acquisition. The method's accuracy for T Results: Phantom studies confirmed accurate T Conclusion: We present the first dynamic and multi-parametric approach for quantitatively tracking contrast agent transport in the mouse brain using 3D MRF.

Indexed as

3DCSFdynamic contrast-enhancedMR fingerprintingT1T2

Identifiers

PMID38745701
PMCPMC11092875

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.