ArticleThe American journal of psychiatry2024
Long-Term Course of Remission and Recovery in Psychotic Disorders.
Article in The American journal of psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Is muscarinic receptor agonist effective and tolerant for schizophrenia?BMC psychiatry · 2025Pooled it
- Safety of rTMS for Schizophrenia: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2025Pooled it
- Childhood premorbid adjustment as a marker for 20-year impairments in schizophrenia spectrum disorder: results from the OPUS study.European child & adolescent psychiatry · 2026Trial
- Long-Term Trajectories of Multidimensional Outcomes in Psychosis Following Early Intervention During the Critical Period: The PEPP-Montreal 10+ Study Protocol.Early intervention in psychiatry · 2026Article
- Symptom predominance, treatment delay, and four-year remission outcomes in first-episode schizophrenia: A single-center cohort from Turkiye.Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi · 2026Article
- Childhood trauma, specifically emotional abuse, is associated with psychiatric symptom severity in drug‑naïve first‑episode patients with schizophrenia.Scientific reports · 2026Article
- Reconsidering the Term "Treatment Resistant Schizophrenia".Schizophrenia bulletin · 2026Article
- Clozapine treatment in the early stages of schizophrenia.Current opinion in psychiatry · 2026Review
- Persistent Psychosis During 4 Years after First Hospitalization for a Psychotic Disorder in the Suffolk County Mental Health Project: Prevalence, Risk Factors, and Relationship to 25-Year Outcomes.Schizophrenia bulletin · 2026Article
- Predictors and Outcomes Associated with 25-Year Cognitive Decline in Psychotic Disorders.Schizophrenia bulletin · 2026Article
- Restoring Course as a Core Diagnostic Element of Psychotic Disorders.Schizophrenia bulletin · 2025Review
- Trial-by-trial ERP-behavior relationships in psychosis: Between- and within-person variability in performance monitoring adjustments.Schizophrenia research · 2025Article
- The Role of Siblings in Caring for Middle-Aged and Older People With Severe Mental Illness: A Scoping Review.International journal of mental health nursing · 2025Article
- Multidimensional outcome of first-episode psychosis: a network analysis.Psychological medicine · 2025Article
- [Long-term courses in schizophrenia : A review of current results and developments].Der Nervenarzt · 2025Review
- Learner experiences of a carer-focused massive open online course on psychosis: A qualitative study.Digital healthArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveUnderstanding prognosis is critical to anticipating public health needs and providing care to individuals with psychotic disorders. However, the long-term course of remission and recovery remains unclear. In this study, the most common trajectories of illness course are described for a cohort of individuals followed for 25 years since first admission for psychosis.
methodsParticipants are from the Suffolk County Mental Health Project, an epidemiological study of first-admission psychosis. Data for the present study was collected from six follow-ups, with 311 individuals assessed at the 25-year follow-up. Common patterns of remission and recovery were assessed in the baseline cohort of 591 individuals and the subsample from the 25-year follow up.
resultsIn the baseline cohort and the 25-year subsample, the most common trajectory for individuals with schizophrenia spectrum disorders was no remission and no recovery. Among individuals with other psychotic disorders, in both the baseline and 25-year cohorts, the modal pattern was one of intermittent remission and recovery. Individuals with other psychotic disorders were more likely to experience stable remission (15.1%) and stable recovery (21.1%), outcomes that were rare among individuals with schizophrenia spectrum disorders (0% and 0.6%, respectively).
conclusionsThe modal longitudinal pattern for individuals with other psychoses is one of multiple transitions into and out of symptomatic and functional recovery. Engagement in a long-term health care plan may help individuals detect and respond to these changes. Sustained remission and recovery are rare among people with schizophrenia spectrum disorders. Efforts should be directed toward developing more effective treatments for this population.
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