Evidence map›Paper›PMID 38745334›Full record

ReviewBioelectronic medicine2024

Unintentionally intentional: unintended effects of spinal stimulation as a platform for multi-modal neurorehabilitation after spinal cord injury.

Gerson N Moreno Romero, Avery R Twyman, Maria F Bandres, Jacob Graves McPherson

Abstract readReview
In one paragraph

Review in Bioelectronic medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gerson N Moreno Romero *Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO, USA.
Avery R Twyman *Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO, USA.
Maria F BandresProgram in Physical Therapy, Washington University School of Medicine, St. Louis, MO, USA.
Jacob Graves McPhersonProgram in Physical Therapy, Washington University School of Medicine, St. Louis, MO, USA. mcpherson.jacob@wustl.edu.ORCID http://orcid.org/0000-0002-4554-7531

Funding

Intraspinal Microstimulation for Multi-modal RehabilitationR01NS111234 · NINDS · WASHINGTON UNIVERSITY · PI MCPHERSON, JACOB GRAVES · 2019 to 2025
$1.8M
NINDS NIH HHS 1R01NS111234NINDS NIH HHS R01 NS111234
6 · The paper itself

Abstract

Electrical stimulation of spinal neurons has emerged as a valuable tool to enhance rehabilitation after spinal cord injury. In separate parameterizations, it has shown promise for improving voluntary movement, reducing symptoms of autonomic dysreflexia, improving functions mediated by muscles of the pelvic floor (e.g., bowel, bladder, and sexual function), reducing spasms and spasticity, and decreasing neuropathic pain, among others. This diverse set of actions is related both to the density of sensorimotor neural networks in the spinal cord and to the intrinsic ability of electrical stimulation to modulate neural transmission in multiple spinal networks simultaneously. It also suggests that certain spinal stimulation parameterizations may be capable of providing multi-modal therapeutic benefits, which would directly address the complex, multi-faceted rehabilitation goals of people living with spinal cord injury. This review is intended to identify and characterize reports of spinal stimulation-based therapies specifically designed to provide multi-modal benefits and those that report relevant unintended effects of spinal stimulation paradigms parameterized to enhance a single consequence of spinal cord injury.

Indexed as

Bioelectronic medicineNeural engineeringNeuromodulationRehabilitationSpinal cord injurySpinal stimulation

Identifiers

PMID38745334
PMCPMC11094943

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.