Evidence map›Paper›PMID 38745140›Full record

ArticleBMC genomics2024

Genomic analysis uncovers novel candidate genes related to adaptation to tropical climates and milk production traits in native goats.

Chenxi Zhang, Hojjat Asadollahpour Nanaei, Niloufar Jafarpour Negari, Mahmoud Amiri Roudbar, Zeinab Amiri Ghanatsaman, Zhannur Niyazbekova, Xiaojun Yang

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Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

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9citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Climate resilience in goats: a comprehensive review of the genetic basis for adaptation to varied climatic conditions.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Review
  9. Review
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Chenxi ZhangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Hojjat Asadollahpour NanaeiCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China. h.asadollahpour@agr.uk.ac.ir.
Niloufar Jafarpour NegariDepartment of Animal Science, Shahid Bahonar University of Kerman, Kerman, 7616914111, Iran.
Mahmoud Amiri RoudbarDepartment of Animal Science, Safiabad-Dezful Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education and Extension Organization (AREEO), Dezful 333, Iran.
Zeinab Amiri GhanatsamanAnimal Science Research Department, Fars Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education and Extension Organization (AREEO), Shiraz, Iran.
Zhannur NiyazbekovaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Xiaojun YangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China. yangxj@nwafu.edu.cn.

Funding

Northwest A and F University 32050410304
6 · The paper itself

Abstract

backgroundSince domestication, both evolutionary forces and human selection have played crucial roles in producing adaptive and economic traits, resulting in animal breeds that have been selected for specific climates and different breeding goals. Pakistani goat breeds have acquired genomic adaptations to their native climate conditions, such as tropical and hot climates. In this study, using next-generation sequencing data, we aimed to assess the signatures of positive selection in three native Pakistani goats, known as milk production breeds, that have been well adapted to their local climate.

resultsTo explore the genomic relationship between studied goat populations and their population structure, whole genome sequence data from native goat populations in Pakistan (n = 26) was merged with available worldwide goat genomic data (n = 184), resulting in a total dataset of 210 individuals. The results showed a high genetic correlation between Pakistani goats and samples from North-East Asia. Across all populations analyzed, a higher linkage disequilibrium (LD) level (- 0.59) was found in the Pakistani goat group at a genomic distance of 1 Kb. Our findings from admixture analysis (K = 5 and K = 6) showed no evidence of shared genomic ancestry between Pakistani goats and other goat populations from Asia. The results from genomic selection analysis revealed several candidate genes related to adaptation to tropical/hot climates (such as; KITLG, HSPB9, HSP70, HSPA12B, and HSPA12B) and milk production related-traits (such as IGFBP3, LPL, LEPR, TSHR, and ACACA) in Pakistani native goat breeds.

conclusionsThe results from this study shed light on the structural variation in the DNA of the three native Pakistani goat breeds. Several candidate genes were discovered for adaptation to tropical/hot climates, immune responses, and milk production traits. The identified genes could be exploited in goat breeding programs to select efficient breeds for tropical/hot climate regions.

Indexed as

GenomicsGoatsLinkage DisequilibriumMilkTropical ClimateAdaptation, PhysiologicalAnimalsBreedingPakistanPhenotypePolymorphism, Single NucleotideSelection, GeneticAdaptationCandidate genesPakistan indigenous goatsPopulation genomicsWhole-genome sequence

Identifiers

PMID38745140
PMCPMC11094986

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