Evidence map›Paper›PMID 38745103›Full record

ReviewNature reviews. Neuroscience2024

The speech neuroprosthesis.

Alexander B Silva, Kaylo T Littlejohn, Jessie R Liu, David A Moses, Edward F Chang

Abstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Trial
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  19. Sensorimotor Theta Oscillations Coordinate Speech Movements.bioRxiv : the preprint server for biology · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexander B SilvaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0838-4136
Kaylo T LittlejohnDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Jessie R LiuDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9316-7624
David A MosesDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Edward F ChangDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA. edward.chang@ucsf.edu.ORCID http://orcid.org/0000-0003-2480-4700

Funding

A Pilot Clinical Trial for Speech NeuroprosthesisU01DC018671 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHANG, EDWARD · 2021 to 2025
$5.6M
Developing a bilingual speech neuroprosthesisF30DC021872 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Budugur Silva · 2024 to 2026
$139k
NIDCD NIH HHS F30 DC021872NIDCD NIH HHS U01 DC018671
6 · The paper itself

Abstract

Loss of speech after paralysis is devastating, but circumventing motor-pathway injury by directly decoding speech from intact cortical activity has the potential to restore natural communication and self-expression. Recent discoveries have defined how key features of speech production are facilitated by the coordinated activity of vocal-tract articulatory and motor-planning cortical representations. In this Review, we highlight such progress and how it has led to successful speech decoding, first in individuals implanted with intracranial electrodes for clinical epilepsy monitoring and subsequently in individuals with paralysis as part of early feasibility clinical trials to restore speech. We discuss high-spatiotemporal-resolution neural interfaces and the adaptation of state-of-the-art speech computational algorithms that have driven rapid and substantial progress in decoding neural activity into text, audible speech, and facial movements. Although restoring natural speech is a long-term goal, speech neuroprostheses already have performance levels that surpass communication rates offered by current assistive-communication technology. Given this accelerated rate of progress in the field, we propose key evaluation metrics for speed and accuracy, among others, to help standardize across studies. We finish by highlighting several directions to more fully explore the multidimensional feature space of speech and language, which will continue to accelerate progress towards a clinically viable speech neuroprosthesis.

Indexed as

Brain-Computer InterfacesSpeechAnimalsHumansNeural Prostheses

Identifiers

PMID38745103
PMCPMC11540306

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.