Evidence map›Paper›PMID 38745101›Full record

ArticleScientific reports2024

Alternative 3'UTR expression induced by T cell activation is regulated in a temporal and signal dependent manner.

Davia Blake, Matthew R Gazzara, Isabel Breuer, Max Ferretti, Kristen W Lynch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Davia BlakeDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Matthew R GazzaraDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Isabel BreuerDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Max FerrettiDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Kristen W LynchDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. klync@pennmedicine.upenn.edu.

Funding

Signal-Induced Regulation of Alternative RNA ProcessingR35GM118048 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KRISTEN W LYNCH · 2016 to 2026
$6.6M
Mechanisms and consequences of 3'UTR isoform diversity in erythropoiesisF31HL162546 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GAZZARA, MATTHEW ROBERT · 2022 to 2024
$136k
CD28 Regulation of Alternative Splicing Changes in Human T cellsF31GM140978 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BLAKE, DAVIA · 2020 to 2023
$90k
NHLBI NIH HHS F31 HL162546NIGMS NIH HHS F31 GM140978NIGMS NIH HHS R35 GM118048
6 · The paper itself

Abstract

The length of 3' untranslated regions (3'UTR) is highly regulated during many transitions in cell state, including T cell activation, through the process of alternative polyadenylation (APA). However, the regulatory mechanisms and functional consequences of APA remain largely unexplored. Here we present a detailed analysis of the temporal and condition-specific regulation of APA following activation of primary human CD4

Indexed as

3' Untranslated RegionsLymphocyte ActivationPolyadenylationCD28 AntigensCD4-Positive T-LymphocytesGene Expression RegulationHumansRNA-Binding ProteinsSignal TransductionT-Lymphocytes3' Untranslated RegionsCD28 AntigensRNA-Binding Proteins3′UTRAlternative polyadenylationCD28CD3T cell receptors

Identifiers

PMID38745101
PMCPMC11094061

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.