Evidence map›Paper›PMID 38745047›Full record

ArticleScientific reports2024

Synthesis and anti-inflammatory activities of two new N-acetyl glucosamine derivatives.

Zhichang Zhang, Weicheng Wang, Peng Xu, Quanjun Cui, Xinlin Yang, Ameer E Hassan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Immunomodulatory Effects ofInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhichang ZhangDepartment of Orthopaedic Surgery, School of Medicine, University of Virginia, 450 Ray C. Hunt Drive, Charlottesville, VA, 22903, USA.
Weicheng WangDepartment of Orthopaedic Surgery, School of Medicine, University of Virginia, 450 Ray C. Hunt Drive, Charlottesville, VA, 22903, USA.
Peng XuDepartment of Pathology, University of Virginia, Charlottesville, 22903, USA.
Quanjun CuiDepartment of Orthopaedic Surgery, School of Medicine, University of Virginia, 450 Ray C. Hunt Drive, Charlottesville, VA, 22903, USA.
Xinlin YangDepartment of Orthopaedic Surgery, School of Medicine, University of Virginia, 450 Ray C. Hunt Drive, Charlottesville, VA, 22903, USA. xy3c@virginia.edu.
Ameer E HassanDepartment of Neuroscience, Valley Baptist Medical Center, 2101 Pease St., Harlingen, TX, 78550, USA. ameerehassan@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N-acetyl glucosamine (NAG) is a natural amino sugar found in various human tissues with previously described anti-inflammatory effects. Various chemical modifications of NAG have been made to promote its biomedical applications. In this study, we synthesized two bi-deoxygenated NAG, BNAG1 and BNAG2 and investigated their anti-inflammatory properties, using an in vivo and in vitro inflammation mouse model induced by lipopolysaccharide (LPS). Among the parent molecule NAG, BNAG1 and BNAG2, BNAG1 showed the highest inhibition against serum levels of IL-6 and TNF α and the leukocyte migration to lungs and peritoneal cavity in LPS challenged mice, as well as IL-6 and TNF α production in LPS-stimulated primary peritoneal macrophages. BNAG2 displayed an anti-inflammatory effect which was comparable to NAG. These findings implied potential application of these novel NAG derivatives, especially BNAG1, in treatment of certain inflammation-related diseases.

Indexed as

AcetylglucosamineAnti-Inflammatory AgentsLipopolysaccharidesMacrophages, PeritonealTumor Necrosis Factor-alphaAnimalsDisease Models, AnimalInflammationInterleukin-6MaleMiceAcetylglucosamineAnti-Inflammatory AgentsInterleukin-6LipopolysaccharidesTumor Necrosis Factor-alphaBi-deoxygenationInflammationMacrophagesN-acetyl glucosamine

Identifiers

PMID38745047
PMCPMC11094000

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.