ArticlePediatric research2025
Quantitative EEG features during the first day correlate to clinical outcome in perinatal asphyxia.
Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Early outcome-prediction with an automated EEG background trend in hypothermia-treated newborns with encephalopathy.Pediatric research · 2026Article
- AI-Driven Quantitative Metabolomics for Early and Precise HIE Diagnosis: Challenges and Solutions.ACS omega · 2025Review
- Neurophysiological changes associated with dysglycemia in term neonates with neonatal encephalopathy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Current Knowledge of Neonatal Birth Asphyxia - a Review of Recent Literature and Novel Approach.Maedica · 2025Review
- Measuring the time it takes to achieve full oral feeding can be used as a low-resource tool to assess neurologic recovery after perinatal asphyxia.Journal of tropical pediatrics · 2025Article
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9 authors.
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Abstract
objectiveTo assess whether computational electroencephalogram (EEG) measures during the first day of life correlate to clinical outcomes in infants with perinatal asphyxia with or without hypoxic-ischemic encephalopathy (HIE).
methodsWe analyzed four-channel EEG monitoring data from 91 newborn infants after perinatal asphyxia. Altogether 42 automatically computed amplitude- and synchrony-related EEG features were extracted as 2-hourly average at very early (6 h) and early (24 h) postnatal age; they were correlated to the severity of HIE in all infants, and to four clinical outcomes available in a subcohort of 40 newborns: time to full oral feeding (nasogastric tube NGT), neonatal brain MRI, Hammersmith Infant Neurological Examination (HINE) at three months, and Griffiths Scales at two years.
resultsAt 6 h, altogether 14 (33%) EEG features correlated significantly to the HIE grade ([r]= 0.39-0.61, p < 0.05), and one feature correlated to NGT ([r]= 0.50). At 24 h, altogether 13 (31%) EEG features correlated significantly to the HIE grade ([r]= 0.39-0.56), six features correlated to NGT ([r]= 0.36-0.49) and HINE ([r]= 0.39-0.61), while no features correlated to MRI or Griffiths Scales.
conclusionsOur results show that the automatically computed measures of early cortical activity may provide outcome biomarkers for clinical and research purposes. IMPACT: The early EEG background and its recovery after perinatal asphyxia reflect initial severity of encephalopathy and its clinical recovery, respectively. Computational EEG features from the early hours of life show robust correlations to HIE grades and to early clinical outcomes. Computational EEG features may have potential to be used as cortical activity biomarkers in early hours after perinatal asphyxia.
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