Evidence map›Paper›PMID 38744898›Full record

ArticleScientific reports2024

Seroprevalence of Toxoplasma gondii and Borrelia burgdorferi infections in patients with multiple sclerosis in Poland.

Agnieszka Pawełczyk, Katarzyna Donskow-Łysoniewska, Ludmiła Szewczak, Magdalena Kierasińska, Maja Machcińska, Rafał Rola, Renata Welc-Falęciak

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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Agnieszka PawełczykDepartment of Immunopathology of Infectious and Parasitic Diseases, Medical University of Warsaw, 3C Pawińskiego Street, 02-106, Warsaw, Poland.
Katarzyna Donskow-ŁysoniewskaLaboratory of Parasitology, General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, Kozielska 4 Street, 01-163, Warsaw, Poland.
Ludmiła SzewczakLaboratory of Parasitology, General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, Kozielska 4 Street, 01-163, Warsaw, Poland.
Magdalena KierasińskaLaboratory of Parasitology, General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, Kozielska 4 Street, 01-163, Warsaw, Poland.
Maja MachcińskaLaboratory of Parasitology, General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, Kozielska 4 Street, 01-163, Warsaw, Poland.
Rafał RolaDepartment of Neurology, Military Institute of Aviation Medicine, Krasińskiego 54/56 Street, 01-755, Warsaw, Poland.
Renata Welc-FalęciakDepartment of Parasitology, Faculty of Biology, University of Warsaw, 1 Miecznikowa Street, 02-096, Warsaw, Poland. r.welc-faleciak@uw.edu.pl.

Funding

the Foundation for Polish Science TEAM TECH/2017-4/22the Ministry of Science and Higher Education, Poland Excellence Initiative - Research University (2020-2026)" in Actions IV.3.1
6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system that affects mainly young people. It is believed that the autoimmune process observed in the pathogenesis of MS is influenced by a complex interaction between genetic and environmental factors, including infectious agents. The results of this study suggest the protective role of Toxoplasma gondii infections in MS. Interestingly, high Toxoplasma IgM seropositivity in MS patients receiving immunomodulatory drugs (IMDs) was identified. On the other hand, Borrelia infections seem to be positively associated with MS. Although the interpretation of our results is limited by the retrospective nature of the studies, the results strongly indicate that further experimental and clinical studies are needed to explain the role of infectious agents in the development and pathophysiological mechanisms of MS.

Indexed as

Borrelia burgdorferiLyme DiseaseMultiple SclerosisToxoplasmaToxoplasmosisAdultFemaleHumansImmunoglobulin MMaleMiddle AgedPolandRetrospective StudiesSeroepidemiologic StudiesYoung AdultImmunoglobulin MBorreliaLyme borreliosisLyme diseaseMultiple sclerosisToxoplasmaToxoplasmosis

Identifiers

PMID38744898
PMCPMC11094124

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.