Evidence map›Paper›PMID 38744812›Full record

ArticleNature communications2024

Premature skewing of T cell receptor clonality and delayed memory expansion in HIV-exposed infants.

Sonwabile Dzanibe, Aaron J Wilk, Susan Canny, Thanmayi Ranganath, Berenice Alinde, Florian Rubelt, Huang Huang, Mark M Davis, Susan P Holmes, Heather B Jaspan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Immune development in early life.Nature immunology · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Joining the dots: maternal cytomegalovirus, HIV and the placenta.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Sonwabile DzanibeDivision of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Aaron J WilkDepartment of Medicine, School of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1430-5852
Susan CannyDepartment of Medicine, School of Medicine, Stanford University, Stanford, CA, USA.
Thanmayi RanganathDepartment of Medicine, School of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9865-2119
Berenice AlindeDivision of Immunology, Department of Biomedical Sciences, Biomedical Research Institute, Stellenbosch University, Cape Town, South Africa.
Florian RubeltDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Huang HuangInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Mark M DavisDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6868-657X
Susan P HolmesDepartment of Statistics, Stanford University, Stanford, CA, USA.
Heather B JaspanDivision of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa. hbjaspan@gmail.com.ORCID http://orcid.org/0000-0002-0745-6073
Catherine A BlishDepartment of Medicine, School of Medicine, Stanford University, Stanford, CA, USA. cblish@stanford.edu.ORCID http://orcid.org/0000-0001-6946-7627
Clive M GrayInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. cgray@sun.ac.za.ORCID http://orcid.org/0000-0002-9293-901X

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
Impact of HIV exposure, feeding status, and microbiome on immune ontogeny and vaccine responses in infantsU01AI131302 · NIAID · STANFORD UNIVERSITY · PI BLISH, CATHERINE A, GRAY, CLIVE MAURICE · 2017 to 2021
$2.1M
MECHANISMS LEADING TO ADVERSE BIRTH OUTCOMES IN SOUTH AFRICAN HIV-INFECTED WOMENR01HD102050 · NICHD · UNIVERSITY OF CAPE TOWN · PI GRAY, CLIVE MAURICE, JASPAN, HEATHER BERYL · 2020 to 2024
$1.7M
Mechanisms of altered immune responses in HIV exposed infantsR21HD083344 · NICHD · UNIVERSITY OF CAPE TOWN · PI GRAY, CLIVE MAURICE, JASPAN, HEATHER BERYL · 2015 to 2016
$415k
Mechanisms by which trophoblasts recruit T cells to the placental villi during maternal HIV and CMV co-infectionR21HD103498 · NICHD · MAYO CLINIC ROCHESTER · PI CHAKRABORTY, RANA, GRAY, CLIVE MAURICE · 2020 to 2021
$390k
Next generation training in HIV research: Immunity in the First 1000 days in mother-infant dyads (TIGRIS)D71TW012265 · FIC · STELLENBOSCH UNIVERSITY · PI CHAKRABORTY, RANA, GRAY, CLIVE MAURICE · 2022 to 2023
$60k
FIC NIH HHS D71 TW012265NIAID NIH HHS U01 AI131302NIAID NIH HHS U19 AI057229NICHD NIH HHS R01 HD102050NICHD NIH HHS R21 HD083344NICHD NIH HHS R21 HD103498U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD102050U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) U01AI131302Wellcome TrustWellcome Trust (Wellcome) 221995/Z/20/Z
6 · The paper itself

Abstract

While preventing vertical HIV transmission has been very successful, HIV-exposed uninfected infants (iHEU) experience an elevated risk to infections compared to HIV-unexposed and uninfected infants (iHUU). Here we present a longitudinal multimodal analysis of infant immune ontogeny that highlights the impact of HIV/ARV exposure. Using mass cytometry, we show alterations in T cell memory differentiation between iHEU and iHUU being significant from week 15 of life. The altered memory T cell differentiation in iHEU was preceded by lower TCR Vβ clonotypic diversity and linked to TCR clonal depletion within the naïve T cell compartment. Compared to iHUU, iHEU had elevated CD56

Indexed as

HIV InfectionsImmunologic MemoryInfectious Disease Transmission, VerticalAdaptive ImmunityCell DifferentiationFemaleHumansInfantInfant, NewbornKiller Cells, NaturalLongitudinal StudiesMaleMemory T CellsReceptors, Antigen, T-CellReceptors, Antigen, T-Cell

Identifiers

PMID38744812
PMCPMC11093981

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.