Inhibitory Effect and Mechanism upon Glucose-Insulin-Potassium Administration on Postpartum Mice with Uterine Cramping Pain.

Guiying Yang, Zonghong Long, Fang Chen, Xiaohang Bao, Dukun Zuo, Hong Tang, Zhuoxi Wu, Hong Li

Abstract read

In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guiying YangDepartment of Anesthesiology, Second Affiliated Hospital of Army Medical University, No.183 Xinqiao Street, 400037, Shapingba, Chongqing, China.

Zonghong LongDepartment of Anesthesiology, Second Affiliated Hospital of Army Medical University, No.183 Xinqiao Street, 400037, Shapingba, Chongqing, China.

Fang ChenDepartment of Anesthesiology, Second Affiliated Hospital of Army Medical University, No.183 Xinqiao Street, 400037, Shapingba, Chongqing, China.

Xiaohang BaoDepartment of Anesthesiology, Second Affiliated Hospital of Army Medical University, No.183 Xinqiao Street, 400037, Shapingba, Chongqing, China.

Dukun ZuoDepartment of Anesthesiology, Second Affiliated Hospital of Army Medical University, No.183 Xinqiao Street, 400037, Shapingba, Chongqing, China.

Hong TangDepartment of Anesthesiology, Second Affiliated Hospital of Army Medical University, No.183 Xinqiao Street, 400037, Shapingba, Chongqing, China.

Zhuoxi WuDepartment of Anesthesiology, Second Affiliated Hospital of Army Medical University, No.183 Xinqiao Street, 400037, Shapingba, Chongqing, China.

Hong LiDepartment of Anesthesiology, Second Affiliated Hospital of Army Medical University, No.183 Xinqiao Street, 400037, Shapingba, Chongqing, China. lh78553@163.com.ORCID 0000-0002-1338-0829

Funding

Population Health Transformation Project (No. CSTB2023TIAD-KPX0047-3).

6 · The paper itself

Abstract

This study aimed to explore the effect of glucose-insulin-potassium (GIK) on postpartum uterine cramping pain(UCP) in mice and the possible underlying mechanisms. Thirty full-term pregnancy C57BL/6 mice, within 6 h after spontaneous labor, the mice were randomly assigned into the following three groups: the control group (group C), the oxytocin group (group O), and the GIK plus oxytocin group (group G). Group G and group O were administered GIK and normal saline, respectively, and 10 min later, oxytocin was injected intraperitoneally; group C received normal saline twice. The pain scores of the mice were assessed after establishment of the postpartum UCP model. The differential expressions of energy metabolism and oxidized lipid metabolites in the uterus were analyzed. The behavioral scores in group G were significantly lower than those in group O (P < 0.05).When compared to group O, group G showed a significant increase in ATP levels (P = 0.046), and group G exhibited elevated levels of amino acids, including L-glutamine, L-aspartic acid, and ornithine. Additionally, phosphate compounds (2-phosphoglyceric acid and 3-phosphoglyceric acid) showed elevated levels. When compared to group O, group G exhibited a decrease in 19R-hydroxy PGF

Indexed as

GlucoseInsulinMice, Inbred C57BLPostpartum PeriodPotassiumAnimalsEnergy MetabolismFemaleMiceOxytocinPregnancyUterusGlucoseInsulinOxytocinPotassiumGIKInadequate analgesiaPostpartum miceUterine cramping pain

Identifiers

PMID38744800

DOI10.1007/s43032-024-01579-8

PMCPMC11393204

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.