Evidence map›Paper›PMID 38744723›Full record

ArticleCalcified tissue international2024

Protective Effects of β-Blockers on Bone in Older Adults with Dementia.

Khiem Khuc, Jude des Bordes, Abayomi Ogunwale, Maria-Bernadette Madel, Catherine Ambrose, Paul Schulz, Florent Elefteriou, Ann Schwartz, Nahid J Rianon

Abstract read
PubMed Publisher
In one paragraph

Article in Calcified tissue international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Khiem KhucDepartment Family and Community Medicine, UTHealth McGovern Medical School, Houston, TX, USA.
Jude des BordesDepartment Family and Community Medicine, UTHealth McGovern Medical School, Houston, TX, USA.
Abayomi OgunwaleDepartment Family and Community Medicine, UTHealth McGovern Medical School, Houston, TX, USA.
Maria-Bernadette MadelDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Catherine AmbroseDepartment of Orthopedic Surgery, UTHealth McGovern Medical School, Houston, TX, USA.
Paul SchulzDepartment of Neurology, UTHealth McGovern Medical School, Houston, TX, USA.
Florent ElefteriouDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Ann SchwartzDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Nahid J RianonDepartment Family and Community Medicine, UTHealth McGovern Medical School, Houston, TX, USA. Nahid.J.Rianon@uth.tmc.edu.ORCID 0000-0003-0075-5836

Funding

Senile Osteoporosis as a Neuroskeletal DiseaseR01AG055394 · NIA · BAYLOR COLLEGE OF MEDICINE · PI ELEFTERIOU, FLORENT · 2017 to 2021
$2.0M
NIA NIH HHS R01 AG055394
6 · The paper itself

Abstract

Increased β-adrenergic receptor activity has been hypothesized to cause bone loss in those with dementia. We investigated the effect of long-term β-blocker use on rate of bone loss in older adults with dementia. We used a linear mixed-effects model to estimate the relationship between long-term β-blocker use and rate of bone loss in participants from the Health Aging and Body Composition study. Records of 1198 participants were analyzed, 44.7% were men. Among the men, 25.2% had dementia and 20.2% were on β-blockers, while in the women, 22.5% had dementia and 16.6% received β-blockers. In the 135 men with dementia, 23 were taking β-blockers, while 15 of 149 women with dementia were using β-blockers. In men with dementia, β-blocker users had 0.00491 g/cm

Indexed as

Adrenergic beta-AntagonistsBone DensityDementiaAgedAged, 80 and overBone and BonesFemaleHumansMaleOsteoporosisAdrenergic beta-AntagonistsBone lossDementiaHealth ABCOlder adultsβ-blockers

Identifiers

PMID38744723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.