Evidence map›Paper›PMID 38744704›Full record

ArticleAbdominal radiology (New York)2024

Adjusting for the effect of IV contrast on automated CT body composition measures during the portal venous phase.

Alexander R Moeller, John W Garrett, Ronald M Summers, Perry J Pickhardt

Abstract read
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In one paragraph

Article in Abdominal radiology (New York), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  3. Opportunistic Screening on Chest CT, From theAJR. American journal of roentgenology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexander R MoellerDepartment of Radiology, University of Wisconsin School of Medicine & Public Health, E3/311 Clinical Science Center 600 Highland Ave., Madison, WI, 53792-3252, USA.
John W GarrettDepartment of Radiology, University of Wisconsin School of Medicine & Public Health, E3/311 Clinical Science Center 600 Highland Ave., Madison, WI, 53792-3252, USA.
Ronald M SummersImaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, USA.
Perry J PickhardtDepartment of Radiology, University of Wisconsin School of Medicine & Public Health, E3/311 Clinical Science Center 600 Highland Ave., Madison, WI, 53792-3252, USA. ppickhardt2@uwhealth.org.ORCID 0000-0002-5534-8202

Funding

Computer Aided Detection for CT ColonographyZIACL040003 · CLC · CLINICAL CENTER · PI SUMMERS, RONALD M. · 2009 to 2025
$0k
6 · The paper itself

Abstract

objectiveFully-automated CT-based algorithms for quantifying numerous biomarkers have been validated for unenhanced abdominal scans. There is great interest in optimizing the documentation and reporting of biophysical measures present on all CT scans for the purposes of opportunistic screening and risk profiling. The purpose of this study was to determine and adjust the effect of intravenous (IV) contrast on these automated body composition measures at routine portal venous phase post-contrast imaging.

methodsFinal study cohort consisted of 1,612 older adults (mean age, 68.0 years; 594 women) all imaged utilizing a uniform CT urothelial protocol consisting of pre-contrast, portal venous, and delayed excretory phases. Fully-automated CT-based algorithms for quantifying numerous biomarkers, including muscle and fat area and density, bone mineral density, and solid organ volume were applied to pre-contrast and portal venous phases. The effect of IV contrast upon these body composition measures was analyzed. Regression analyses, including square of the Pearson correlation coefficient (r

resultsWe found that simple, linear relationships can be derived to determine non-contrast equivalent values from the post-contrast CT biomeasures. Excellent positive linear correlation (r

conclusionFully-automated quantitative CT-biomarker measures at portal venous phase abdominal CT can be adjusted to a non-contrast equivalent using simple, linear relationships.

Indexed as

Body CompositionContrast MediaPortal VeinTomography, X-Ray ComputedAgedAged, 80 and overAlgorithmsBiomarkersFemaleHumansMaleMiddle AgedRadiographic Image Interpretation, Computer-AssistedBiomarkersContrast MediaAbdomenCTDeep learningMachine learning

Identifiers

PMID38744704

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.