Evidence map›Paper›PMID 38744698›Full record

ArticleAbdominal radiology (New York)2024

A combined model based on radiomics features of Sonazoid contrast-enhanced ultrasound in the Kupffer phase for the diagnosis of well-differentiated hepatocellular carcinoma and atypical focal liver lesions: a prospective, multicenter study.

Zhen Wang, Jundong Yao, Xiang Jing, Kaiyan Li, ShiChun Lu, Hong Yang, Hong Ding, Kai Li, Wen Cheng, Guangzhi He and 14 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Abdominal radiology (New York), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Zhen Wang *Medical School of Chinese PLA, 28 Fuxing Road, Beijing, 100853, China.
Jundong Yao *Department of Interventional Ultrasound, First Medical Center of Chinese, PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China.
Xiang JingDepartment of Ultrasound, Tianjin Third Central Hospital, Tianjin, China.
Kaiyan LiDepartment of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
ShiChun LuDepartment of Hepatobiliary Surgery, The First Medical Centre, Chinese PLA General Hospital, Beijing, China.
Hong YangDepartment of Medical Ultrasonics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Hong DingDepartment of Ultrasound, Huashan Hospital, Fudan University, Shanghai, China.
Kai LiDepartment of Ultrasound, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Wen ChengDepartment of Ultrasonography, Harbin Medical University Cancer Hospital, Harbin, China.
Guangzhi HeDepartment of Ultrasound, University of Chinese Academy of Sciences Shenzhen Hospital, Guangming District, Shenzhen, China.
Tianan JiangDepartment of Ultrasound Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Fangyi LiuDepartment of Interventional Ultrasound, First Medical Center of Chinese, PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China.
Jie YuDepartment of Interventional Ultrasound, First Medical Center of Chinese, PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China.
Zhiyu HanDepartment of Interventional Ultrasound, Fifth Medical Center of Chinese, PLA General Hospital, Beijing, China.
Zhigang ChengDepartment of Interventional Ultrasound, Fifth Medical Center of Chinese, PLA General Hospital, Beijing, China.
Shuilian TanDepartment of Interventional Ultrasound, Fifth Medical Center of Chinese, PLA General Hospital, Beijing, China.
Zhen WangDepartment of Interventional Ultrasound, Fifth Medical Center of Chinese, PLA General Hospital, Beijing, China.
Erpeng QiDepartment of Interventional Ultrasound, Fifth Medical Center of Chinese, PLA General Hospital, Beijing, China.
Shuo WangDepartment of Interventional Ultrasound, First Medical Center of Chinese, PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China.
YiQiong ZhangDepartment of Interventional Ultrasound, First Medical Center of Chinese, PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China.
Lu LiMedical School of Chinese PLA, 28 Fuxing Road, Beijing, 100853, China.
Xiaocong DongDepartment of Interventional Ultrasound, First Medical Center of Chinese, PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China.
Ping Liang *Department of Interventional Ultrasound, Fifth Medical Center of Chinese, PLA General Hospital, Beijing, China. liangping301@hotmail.com.
Xiaoling Yu *Department of Interventional Ultrasound, First Medical Center of Chinese, PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China. dyuxl301@aliyun.com.ORCID 0000-0003-1349-2334

Funding

National Scientific Foundation Committee of China 82172027
6 · The paper itself

Abstract

objectiveThe objective of this study was to develop a combined model based on radiomics features of Sonazoid contrast-enhanced ultrasound (CEUS) during the Kupffer phase and to evaluate its value in differentiating well-differentiated hepatocellular carcinoma (w-HCC) from atypical benign focal liver lesions (FLLs).

methodsA total of 116 patients with preoperatively Sonazoid-CEUS confirmed w-HCC or benign FLL were selected from a prospective multiple study on the clinical application of Sonazoid in FLLs conducted from August 2020 to March 2021. According to the randomization principle, the patients were divided into a training cohort and a test cohort in a 7:3 ratio. Seventy-nine patients were used for establishing and training the radiomics model and combined model. In comparison, 37 patients were used for validating and comparing the performance of the models. The diagnostic efficacy of the models for w-HCC and atypical benign FLLs was evaluated using ROCs curves and decision curves. A combined model nomogram was created to assess its value in reducing unnecessary biopsies.

resultsAmong the patients, there were 55 cases of w-HCC and 61 cases of atypical benign FLLs, including 28 cases of early liver abscess, 16 cases of atypical hepatic hemangioma, 8 cases of hepatocellular dysplastic nodules (DN), and 9 cases of focal nodular hyperplasia (FNH). The radiomics model and combined model we established had AUCs of 0.905 and 0.951, respectively, in the training cohort, and the AUCs of the two models in the test cohort were 0.826 and 0.912, respectively. The combined model outperformed the radiomics feature model significantly. Decision curve analysis demonstrated that the combined model achieved a higher net benefit within a specific threshold probability range (0.25 to 1.00). A nomogram of the combined model was developed.

conclusionThe combined model based on the radiomics features of Sonazoid-CEUS in the Kupffer phase showed satisfactory performance in diagnosing w-HCC and atypical benign FLLs. It can assist clinicians in timely detecting malignant FLLs and reducing unnecessary biopsies for benign diseases.

Indexed as

Carcinoma, HepatocellularContrast MediaFerric CompoundsIronLiver NeoplasmsOxidesUltrasonographyAdultAgedDiagnosis, DifferentialFemaleHumansLiverMaleMiddle AgedProspective StudiesContrast MediaFerric CompoundsIronOxidesSonazoidContrast-enhanced ultrasoundFocal liver lesionKupffer phaseSonazoid

Identifiers

PMID38744698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.