Evidence map›Paper›PMID 38744684›Full record

ArticleInfluenza and other respiratory viruses2024

End of 2022/23 Season Influenza Vaccine Effectiveness in Primary Care in Great Britain.

Heather J Whitaker, Naoma Willam, Simon Cottrell, Rosalind Goudie, Nick Andrews, Josie Evans, Catherine Moore, Utkarsh Agrawal, Katie Hassell, Rory Gunson and 20 more

Abstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Early influenza virus characterisation and vaccine effectiveness in England in autumn 2025, a period dominated by influenza A(H3N2) subclade K.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  3. Article
  4. Interim 2024/25 influenza vaccine effectiveness: eight European studies, September 2024 to January 2025.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Heather J WhitakerStatistics, Modelling and Economics Department, UK Health Security Agency, London, UK.ORCID 0000-0001-5833-1863
Naoma WillamClinical and Protecting Health, Public Health Scotland, Glasgow, UK.
Simon CottrellPublic Health Wales Communicable Disease Surveillance Centre, Public Health Wales, Cardiff, UK.
Rosalind GoudieNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Nick AndrewsImmunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, UK.
Josie EvansClinical and Protecting Health, Public Health Scotland, Glasgow, UK.
Catherine MooreWales Specialist Virology Centre, Public Health Wales Microbiology, Cardiff, UK.
Utkarsh AgrawalNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Katie HassellImmunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, UK.
Rory GunsonWest of Scotland Specialist Virology Centre, NHS Greater Glasgow and Clyde, Glasgow, UK.
Jana ZithaPublic Health Wales Communicable Disease Surveillance Centre, Public Health Wales, Cardiff, UK.ORCID 0000-0001-5561-1739
Sneha AnandNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Praveen Sebastian-PillaiRespiratory Virus Unit, UK Health Security Agency, London, UK.
Panoraia KalapotharakouPublic Health Wales Communicable Disease Surveillance Centre, Public Health Wales, Cardiff, UK.
Cecilia OkusiNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Katja HoschlerRespiratory Virus Unit, UK Health Security Agency, London, UK.
Gavin JamieNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.ORCID 0000-0001-9147-7784
Beatrix KeleRespiratory Virus Unit, UK Health Security Agency, London, UK.ORCID 0000-0003-1273-7299
Mark HamiltonClinical and Protecting Health, Public Health Scotland, Glasgow, UK.
Anastasia CouzensWales Specialist Virology Centre, Public Health Wales Microbiology, Cardiff, UK.
Catherine QuinotImmunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, UK.
Kathleen PheasantWales Specialist Virology Centre, Public Health Wales Microbiology, Cardiff, UK.
Rachel ByfordNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Kimberly MarshClinical and Protecting Health, Public Health Scotland, Glasgow, UK.
Chris RobertsonDepartment of Mathematics and Statistics, University of Strathclyde, Glasgow, UK.
Simon de LusignanNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Christopher WilliamsPublic Health Wales Communicable Disease Surveillance Centre, Public Health Wales, Cardiff, UK.
Maria ZambonRespiratory Virus Unit, UK Health Security Agency, London, UK.
Jim McMenaminClinical and Protecting Health, Public Health Scotland, Glasgow, UK.
Conall H WatsonImmunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, UK.

Funding

Public Health ScotlandPublic Health WalesUK Health Security Agency
6 · The paper itself

Abstract

backgroundThe 2022/23 influenza season in the United Kingdom saw the return of influenza to prepandemic levels following two seasons with low influenza activity. The early season was dominated by A(H3N2), with cocirculation of A(H1N1), reaching a peak late December 2022, while influenza B circulated at low levels during the latter part of the season. From September to March 2022/23, influenza vaccines were offered, free of charge, to all aged 2-13 (and 14-15 in Scotland and Wales), adults up to 49 years of age with clinical risk conditions and adults aged 50 and above across the mainland United Kingdom.

methodsEnd-of-season adjusted vaccine effectiveness (VE) estimates against sentinel primary-care attendance for influenza-like illness, where influenza infection was laboratory confirmed, were calculated using the test negative design, adjusting for potential confounders.

methodsResults In the mainland United Kingdom, end-of-season VE against all laboratory-confirmed influenza for all those > 65 years of age, most of whom received adjuvanted quadrivalent vaccines, was 30% (95% CI: -6% to 54%). VE for those aged 18-64, who largely received cell-based vaccines, was 47% (95% CI: 37%-56%). Overall VE for 2-17 year olds, predominantly receiving live attenuated vaccines, was 66% (95% CI: 53%-76%).

conclusionThe paper provides evidence of moderate influenza VE in 2022/23.

Indexed as

Influenza A Virus, H3N2 SubtypeInfluenza B virusInfluenza, HumanInfluenza VaccinesPrimary Health CareVaccine EfficacyAdolescentAdultAgedChildChild, PreschoolFemaleHumansInfluenza A Virus, H1N1 SubtypeMaleMiddle AgedInfluenza Vaccineseffectivenessinfluenzavaccine

Identifiers

PMID38744684
PMCPMC11093773

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.