Evidence map›Paper›PMID 38744503›Full record

ArticleGenes & development2024

H2A.Z chaperones converge on E2F target genes for melanoma cell proliferation.

Sina Jostes, Chiara Vardabasso, Joanna Dong, Saul Carcamo, Rajendra Singh, Robert Phelps, Austin Meadows, Elena Grossi, Dan Hasson, Emily Bernstein

Abstract read
In one paragraph

Article in Genes & development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Single-cell transcriptomics identifies anFrontiers in molecular biosciences · 2025
    Article
  10. The Clonal Hematopoiesis-associated GenebioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Sina JostesDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Chiara Vardabasso *Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Joanna Dong *Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Saul CarcamoTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Rajendra SinghDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Robert PhelpsDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Austin MeadowsDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Elena GrossiDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Dan HassonDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Emily BernsteinDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA; emily.bernstein@mssm.edu.

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4M
Skin Biology and Diseases Resource-based Center at Mount SinaiP30AR079200 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Elena Ezhkova · 2021 to 2026
$5.2M
Deciphering the tumor suppressive functions of macroH2AR01CA154683 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BERNSTEIN, EMILY · 2011 to 2021
$3.9M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
NCATS NIH HHS UL1 TR004419NCI NIH HHS P30 CA196521NCI NIH HHS R01 CA154683NIAMS NIH HHS P30 AR079200NIH HHS S10 OD026880
6 · The paper itself

Abstract

High levels of H2A.Z promote melanoma cell proliferation and correlate with poor prognosis. However, the role of the two distinct H2A.Z histone chaperone complexes SRCAP and P400-TIP60 in melanoma remains unclear. Here, we show that individual subunit depletion of

Indexed as

Cell ProliferationGene Expression Regulation, NeoplasticHistonesMelanomaAcetylationApoptosisCell Line, TumorE2F1 Transcription FactorHumansMolecular ChaperonesE2F1 Transcription Factorhistone H2A.F-ZHistonesMolecular ChaperonesepigeneticsH2A.Zhistone chaperoneshistone variantsmelanoma

Identifiers

PMID38744503
PMCPMC11146596

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.