Evidence map›Paper›PMID 38744380›Full record

ArticleFitoterapia2024

Six new diterpenoids with anti-inflammatory and cytotoxic activity from Isodon serra.

Xiaoying Liu, Zhiwei Bian, Yintai Tian, Hongyi Li, Shian Hu, Cheng Li, Pankaj Pandey, Daneel Ferreira, Amar Gopal Chittiboyina, Mark T Hamann and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fitoterapia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaoying LiuSchool of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu, China.
Zhiwei BianSchool of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu, China.
Yintai TianSchool of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu, China.
Hongyi LiState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
Shian HuSchool of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu, China.
Cheng LiSinopharm Lanzhou Biopharmaceuticals Co.,Ltd., Lanzhou 730000, Gansu, China.
Pankaj PandeyNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, USA.
Daneel FerreiraDepartment of Biomolecular Sciences, Division of Pharmacognosy, and National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, USA.
Amar Gopal ChittiboyinaNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, USA.
Mark T HamannDrug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC, USA.
Xingchuan MaDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, 44106 Cleveland, OH, USA.
Shengpeng WangState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
Xiaojuan WangSchool of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu, China.

Funding

Synthesis and Optimization of the Aleutianamine Class of AlkaloidsR01GM145845 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HAMANN, MARK T, TIUS, MARCUS ANTONIUS · 2022 to 2025
$2.4M
Natural Product HCV Drugs from Rare Plant-Microbe InteractionsR01AT007318 · NCCIH · UNIVERSITY OF MISSISSIPPI · PI HAMANN, MARK T · 2012 to 2016
$1.6M
NCCIH NIH HHS R01 AT007318NIGMS NIH HHS R01 GM145845
6 · The paper itself

Abstract

Diterpenoids occupy an important slot of the natural products diversity space with wide ranges of bioactivities and complex structures, providing potential applications for the development of therapeutics. In this study, we reported four new abietane-type diterpenoids viroxocin B-E (1-4), a new totarane-type diterpenoid viroxocin F (5), and a new sempervirane-type diterpenoid viroxocin G (6) along with four known compounds (7-10), isolated and identified from a widely used Traditional Chinese Medicine, Isodon serra (I. serra). Their structures were established by spectroscopic data analysis, experimental and calculated electronic circular dichroism (ECD) data, as well as X-ray diffraction analysis. Compounds 2, 5, 7, 8 and 10 exhibited promising anti-inflammatory activities in lipopolysaccharide (LPS)-induced RAW 267.4 cells, and their inhibition rates on NO production were more than 60% at 10 μM. Compound 7 showed cytotoxicity against human renal cell carcinoma 769P at 20 μM, the inhibition rate was 52.66%.

Indexed as

Anti-Inflammatory AgentsAntineoplastic Agents, PhytogenicDiterpenesIsodonPhytochemicalsAnimalsCell Line, TumorChinaHumansMiceMolecular StructureNitric OxideRAW 264.7 CellsAnti-Inflammatory AgentsAntineoplastic Agents, PhytogenicDiterpenesNitric OxidePhytochemicalsAnti-inflammatoryCytotoxicityDiterpenoidsIsodon Serra

Identifiers

PMID38744380
PMCPMC12582105

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.