Evidence map›Paper›PMID 38744354›Full record

ReviewThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2024

Deactivation of LVAD support for myocardial recovery-surgical perspectives.

Ian Nickel, Evgenij Potapov, Benjamin Sun, Daniel Zimpfer, Antigone Koliopoulou, Iki Adachi, Anelechi Anyanwu, Volkmar Falk, Pavan Atluri, Gloria Faerber and 12 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Metabolic Reprogramming in Heart Failure: From Energy Starvation to Therapeutic Targets.Current treatment options in cardiovascular medicine · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Ian NickelDepartment of Cardiothoracic Surgery, University of Utah, Salt Lake City, Utah.
Evgenij PotapovDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.
Benjamin SunDivision of Cardiothoracic Surgery, Abbott Northwestern Hospital, Minneapolis Heart Institute, Minneapolis, Minnesota.
Daniel ZimpferDepartment of Cardiac Surgery, Medical University Vienna, Vienna, Austria.
Antigone KoliopoulouHeart Failure, Transplant and Mechanical Circulatory Support Units, Onassis Cardiac Surgery Center, Athens, Greece.
Iki AdachiDivision of Congenital Heart Surgery, Michael E. DeBakey Department of Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
Anelechi AnyanwuDepartment of Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.
Volkmar FalkDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany; Department of Health Sciences and Technology, Translational Cardiovascular Technologies, Institute of Translational Medicine, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland.
Pavan AtluriDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
Gloria FaerberDepartment of Cardiothoracic Surgery, Jena University Hospital-Friedrich Schiller University of Jena, Jena, Germany.
Daniel GoldsteinDepartment of Cardiothoracic and Vascular Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, New York, New York.
Leora YarboroDivision of Cardiac Surgery, Department of Surgery, University of Virginia, Charlottesville, Virginia.
Mark S SlaughterDepartment of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Kentucky.
Carmelo MilanoDepartment of Thoracic and Cardiovascular Surgery, Duke University Medical Center, Durham, North Carolina.
Masaki TsukashitaDepartment of Cardiothoracic Surgery, Cardiovascular Institute, Allegheny Health Network, Pittsburgh, Pennsylvania.
David D'AlessandroDivision of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.
Scott SilvestryDepartment of Cardiothoracic Surgery, AdventHealth Transplant Institute, Orlando, Florida.
Hristo KirovDepartment of Cardiothoracic Surgery, Jena University Hospital-Friedrich Schiller University of Jena, Jena, Germany.
Swaroop BommareddiDepartment of Cardiac Surgery, Vanderbilt University, Nashville, Tennessee.
Pia LanmüllerDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.
Torsten DoenstDepartment of Cardiothoracic Surgery, Jena University Hospital-Friedrich Schiller University of Jena, Jena, Germany.
Craig H SelzmanDepartment of Cardiothoracic Surgery, University of Utah, Salt Lake City, Utah. Electronic address: Craig.selzman@hsc.utah.edu.

Funding

TRAINING IN CARDIOVASCULAR RESEARCHT32HL007576 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos, Robin M Shaw · 1985 to 2026
$10.6M
NHLBI NIH HHS T32 HL007576
6 · The paper itself

Abstract

Left ventricular assist devices (LVADs) are excellent therapies for advanced heart failure patients either bridged to transplant or for lifetime use. LVADs also allow for reverse remodeling of the failing heart that is often associated with functional improvement. Indeed, growing enthusiasm exists to better understand this population of patients, whereby the LVAD is used as an adjunct to mediate myocardial recovery. When patients achieve benchmarks suggesting that they no longer need LVAD support, questions related to the discontinuation of LVAD therapy become front and center. The purpose of this review is to provide a surgical perspective on the practical and technical issues surrounding LVAD deactivation.

Indexed as

Heart-Assist DevicesHeart FailureRecovery of FunctionHeart TransplantationHumansVentricular RemodelingWithholding Treatmentdecommissioningexplantheart failuremechanical circulatory supportmyocardial recoveryVAD

Identifiers

PMID38744354
PMCPMC12952964

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.