Evidence map›Paper›PMID 38744108›Full record

ArticleDrug and alcohol dependence2024

E-cigarette dependence and cooling flavor use are linked among youth.

Wei Li, Danielle R Davis, Grace Kong, Krysten W Bold, Meghan E Morean, Deepa Camenga, Akshika Sharma, Juhan Lee, Suchitra Krishnan-Sarin

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Abuse Liability of Electronic Cigarettes in Never-Smoking Electronic Cigarette Users.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Trial
  2. Article
  3. Article
  4. Article
  5. Preventive medicine reports · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei LiDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA. Electronic address: Wei.vanness.li@yale.edu.
Danielle R DavisDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Grace KongDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Krysten W BoldDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Meghan E MoreanDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Deepa CamengaDepartment of Emergency Medicine, Yale School of Medicine, New Haven, CT, USA.
Akshika SharmaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Juhan LeeDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Suchitra Krishnan-SarinDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Center for the Study of Tobacco Product Use and Addiction (YCSTP) Project 2: Addictive Threshold of Nicotine and the Impact of SweetenersU54DA036151 · NIDA · YALE UNIVERSITY · PI LISA M FUCITO · 2018 to 2026
$41.6M
NCATS NIH HHS UL1 TR001863NIDA NIH HHS U54 DA036151
6 · The paper itself

Abstract

backgroundE-cigarette flavors that produce cooling sensations may reduce nicotine harshness and enhance appeal among youth. While previous research has shown that use of cooling flavors is associated with more frequent vaping among youth, it is unknown whether the same holds true for e-cigarette dependence. This study examines the relationship between cooling flavor use and e-cigarette dependence among youth accounting for vaping frequency.

methodsIn Fall 2022, a survey was conducted among Connecticut high school students to assess past-month nicotine e-cigarette use, ever use of cooling flavors, cooling flavor types (e.g., fruit-cooling), and e-cigarette dependence. Analyses were restricted to those with past-month nicotine and nicotine-free e-cigarette use and complete data (n=204). Multivariable linear regressions were run to examine the association between cooling flavor use and e-cigarette dependence, adjusting for demographics, e-cigarette use characteristics, and other tobacco product use.

results78.4% of the sample used cooling e-cigarette flavors, with 55.0% using mint-cooling flavors and 52.5% using fruit-cooling flavors. Regression results observed that cooling flavor use was associated with higher e-cigarette dependence (ꞵ=1.53, SE=0.63, p=0.017), with those who used cooling flavors having higher e-cigarette dependence than those who did not (M=5.78 [SD=5.33] vs. 2.84 [3.19]).

conclusionsOur results suggest that cooling flavor use is significantly associated with e-cigarette dependence among youth. While regulations often target menthol flavor, tobacco control agencies should consider restricting any flavor that can produce cooling sensations, even if they are not traditional menthol products, as cooling flavors is associated with youth e-cigarette dependence.

Indexed as

Electronic Nicotine Delivery SystemsFlavoring AgentsVapingAdolescentConnecticutFemaleHumansMaleStudentsTobacco Use DisorderFlavoring AgentsCooling flavorsDependenceE-cigarettesENDSYouth

Identifiers

PMID38744108
PMCPMC11612924

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.