Evidence map›Paper›PMID 38744031›Full record

ArticleJournal of pharmaceutical and biomedical analysis2024

Development and validation of a sensitive LC-MS/MS assay of GT-14, a novel Gα

Mahua Sarkar, Jing Ma, Subhasish Tapadar, Silvia Caggia, Adegboyega K Oyelere, Shafiq A Khan, Huan Xie

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical and biomedical analysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mahua SarkarDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.
Jing MaDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.
Subhasish TapadarSchool of Chemistry and Biochemistry, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30318, USA.
Silvia CaggiaCenter for Cancer Research and Therapeutic Development, Clark Atlanta University, 223 James P. Brawley Dr, Atlanta, GA 30314, USA.
Adegboyega K OyelereSchool of Chemistry and Biochemistry, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30318, USA.
Shafiq A KhanCenter for Cancer Research and Therapeutic Development, Clark Atlanta University, 223 James P. Brawley Dr, Atlanta, GA 30314, USA.
Huan XieDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA. Electronic address: huan.xie@tsu.edu.

Funding

Targeted Nano-drug-delivery-systems of Frist-in-class Drugs for CRPC: PK/PD Evaluation and Combination TherapyU54MD007605 · NIMHD · TEXAS SOUTHERN UNIVERSITY · PI Creaque C Tyler · 2020 to 2026
$22.0M
Center for Biomedical and Health Research Excellence (CBHRE)G12MD007605 · NIMHD · TEXAS SOUTHERN UNIVERSITY · PI OYEKAN, ADEBAYO O., WILSON, BOBBY L · 2014 to 2018
$7.1M
NIMHD NIH HHS G12 MD007605NIMHD NIH HHS U54 MD007605
6 · The paper itself

Abstract

A sensitive and selective LC-MS/MS method was developed and validated for the quantitation of a novel Gα

Indexed as

GriseofulvinAnimalsLiquid Chromatography-Mass SpectrometryMaleProtein BindingRatsRats, Sprague-DawleyReproducibility of ResultsSpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryGriseofulvinGαi2 inhibitorLC-MS/MSPharmacokineticsPlasma Protein BindingValidation

Identifiers

PMID38744031
PMCPMC11138141

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.