ArticlePLoS biology2024
Spiking activity in the visual thalamus is coupled to pupil dynamics across temporal scales.
Article in PLoS biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Dynamic salience as a basis for behavioural meta-malleability.Royal Society open science · 2026Review
- Epineuronal space: an emerging hidden hierarchy bridges neuron and mind space.Cell & bioscience · 2026Review
- Dynamic Modulation of Beta-Band Oscillations in the LGN and Their Role in Visual Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
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- Orexin population activity precisely reflects net body movement across behavioral and metabolic states.eLife · 2025Article
- Autonomic Nervous System, Cognition, and Emotional Valence During Different Phases of the Menstrual Cycle-A Narrative Review.NeuroSci · 2025Review
- Pupil size modulation drives retinal activity in mice and shapes human perception.Nature communications · 2025Article
- Adaptive arousal regulation: Pharmacologically shifting the peak of the Yerkes-Dodson curve by catecholaminergic enhancement of arousal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Effects of corticothalamic feedback depend on visual responsiveness and stimulus type.iScience · 2025Article
- Environmental context influences visual processing in thalamus.Current biology : CB · 2025Article
- The Interplay of Spontaneous Pupil-Size Fluctuations and EEG Power in Near-Threshold Detection.Psychophysiology · 2025Article
- Deciphering neuronal variability across states reveals dynamic sensory encoding.Nature communications · 2025Article
- What the eyes, confidence, and partner's identity can tell about change of mind.Neuroscience of consciousness · 2024Article
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Authors and funding
4 authors.
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Abstract
The processing of sensory information, even at early stages, is influenced by the internal state of the animal. Internal states, such as arousal, are often characterized by relating neural activity to a single "level" of arousal, defined by a behavioral indicator such as pupil size. In this study, we expand the understanding of arousal-related modulations in sensory systems by uncovering multiple timescales of pupil dynamics and their relationship to neural activity. Specifically, we observed a robust coupling between spiking activity in the mouse dorsolateral geniculate nucleus (dLGN) of the thalamus and pupil dynamics across timescales spanning a few seconds to several minutes. Throughout all these timescales, 2 distinct spiking modes-individual tonic spikes and tightly clustered bursts of spikes-preferred opposite phases of pupil dynamics. This multi-scale coupling reveals modulations distinct from those captured by pupil size per se, locomotion, and eye movements. Furthermore, coupling persisted even during viewing of a naturalistic movie, where it contributed to differences in the encoding of visual information. We conclude that dLGN spiking activity is under the simultaneous influence of multiple arousal-related processes associated with pupil dynamics occurring over a broad range of timescales.
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