Evidence map›Paper›PMID 38743370›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2024

Setup of Aerosol Delivery System to Prevent Measles Virus Infection in Nonhuman Primate Model.

Olivier Reynard, Jérôme Montharu, Mathieu Iampietro, Claudia Gonzalez, Sandrine Le Guellec, Branka Horvat, Laurent Vecellio

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Olivier ReynardCIRI, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon, Lyon, France. Olivier.reynard@inserm.fr.ORCID 0000-0001-7536-355X
Jérôme MontharuPST-A, University of Tours, Tours, France.
Mathieu IampietroCIRI, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon, Lyon, France.
Claudia GonzalezCIRI, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon, Lyon, France.
Sandrine Le GuellecFaculté de médecine, DTF-Aerodrug, R&D Aerosoltherapy Department of DTF medical (Saint Etienne, France), Université de Tours, Tours, France.
Branka HorvatCIRI, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon, Lyon, France.
Laurent VecellioPST-A, University of Tours, Tours, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Measles virus is one of the most contagious airborne human viruses which keeps causing outbreaks in numerous countries over the world despite the existence of an efficient vaccine. Fusion inhibitory lipopeptides were shown to inhibit viral entry into target cells, and their adequate administration into the respiratory tract may provide a novel preventive approach against airborne infections. Aerosol delivery presents the best administration route to deliver such preventive compounds to the upper and lower respiratory tract. This approach offers a conceptually new strategy to protect the population at risk against infection by respiratory viruses, including measles. It is a noninvasive needle-free approach, which may be used when antiviral protection is required, without any medical assistance. In this chapter, we describe the nebulization approach of lipopeptide compounds in nonhuman primates and the subsequent measles virus challenge.

Indexed as

AerosolsDisease Models, AnimalMeaslesMeasles virusAnimalsDrug Delivery SystemsHumansLipopeptidesAerosolsLipopeptidesFusion inhibitorLipopeptideMeaslesNebulizationNonhuman primateParamyxovirus

Identifiers

PMID38743370

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.