ArticleThe Journal of physiology2024
Mitochondrial respiration is lower in the intrauterine growth-restricted fetal sheep heart.
Article in The Journal of physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Glucocorticoids in pregnancy: a master-switch for fetal maturation.Endocrine reviews · 2026Review
- Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease.The Journal of physiology · 2026Review
- Fetal glucose availability: a key regulator of the metabolic, hormonal and contractility profiles of the fetal sheep heart.The Journal of physiology · 2026Article
- Reactive oxygen species in fetal growth restriction mechanisms and therapeutic directions (Review).International journal of molecular medicine · 2026Review
- Sex-specific cardiac remodeling and metabolic reprogramming in IUGR F2 fetuses following glyphosate or glyphosate-based herbicide exposure.Frontiers in toxicology · 2026Article
- Placental insufficiency disrupts cardiomyocyte ploidy and cell cycle fate in growth-restricted fetal sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Compromised cardiopulmonary transition in fetal growth restricted and small for gestational age neonates.The Journal of physiology · 2025Review
- Developmental regulation of fetal mitochondrial respiratory function towards term: the role of glucocorticoid and thyroid hormones.The Journal of endocrinology · 2025Review
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Authors and funding
8 authors.
Funding
Abstract
Fetuses affected by intrauterine growth restriction have an increased risk of developing heart disease and failure in adulthood. Compared with controls, late gestation intrauterine growth-restricted (IUGR) fetal sheep have fewer binucleated cardiomyocytes, reflecting a more immature heart, which may reduce mitochondrial capacity to oxidize substrates. We hypothesized that the late gestation IUGR fetal heart has a lower capacity for mitochondrial oxidative phosphorylation. Left (LV) and right (RV) ventricles from IUGR and control (CON) fetal sheep at 90% gestation were harvested. Mitochondrial respiration (states 1-3, Leak
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Registered trials
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