Evidence map›Paper›PMID 38742971›Full record

ArticleRadiology2024

Precision and Test-Retest Repeatability of Stiffness Measurement with MR Elastography: A Multicenter Phantom Study.

Efe Ozkaya, Paul Kennedy, Jun Chen, Octavia Bane, Jonathan R Dillman, Kartik S Jhaveri, Michael A Ohliger, Phillip J Rossman, Jean A Tkach, John T Doucette and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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  6. Review
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  12. Non-invasive diagnosis of liver fibrosis via MRI using targeted gadolinium-based nanoparticles.European journal of nuclear medicine and molecular imaging · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Efe Ozkaya *From the BioMedical Engineering and Imaging Institute (E.O., P.K., O.B., B.T.) and Departments of Diagnostic, Molecular and Interventional Radiology (E.O., P.K., O.B., B.T.) Environmental Medicine and Public Health (J.T.D.), Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029; Department of Radiology, Mayo Clinic, Rochester, Minn (J.C., P.J.R., S.K.V., R.L.E.); Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China (J.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D., J.A.T.); Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women's College Hospital, University of Toronto, Toronto, Canada (K.S.J.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (M.A.O.); and Department of Radiology, Zuckerberg San Francisco General Hospital, San Francisco, Calif (M.A.O.).ORCID 0000-0003-0583-7507
Paul Kennedy *From the BioMedical Engineering and Imaging Institute (E.O., P.K., O.B., B.T.) and Departments of Diagnostic, Molecular and Interventional Radiology (E.O., P.K., O.B., B.T.) Environmental Medicine and Public Health (J.T.D.), Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029; Department of Radiology, Mayo Clinic, Rochester, Minn (J.C., P.J.R., S.K.V., R.L.E.); Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China (J.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D., J.A.T.); Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women's College Hospital, University of Toronto, Toronto, Canada (K.S.J.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (M.A.O.); and Department of Radiology, Zuckerberg San Francisco General Hospital, San Francisco, Calif (M.A.O.).ORCID 0000-0003-4295-3670
Jun ChenFrom the BioMedical Engineering and Imaging Institute (E.O., P.K., O.B., B.T.) and Departments of Diagnostic, Molecular and Interventional Radiology (E.O., P.K., O.B., B.T.) Environmental Medicine and Public Health (J.T.D.), Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029; Department of Radiology, Mayo Clinic, Rochester, Minn (J.C., P.J.R., S.K.V., R.L.E.); Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China (J.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D., J.A.T.); Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women's College Hospital, University of Toronto, Toronto, Canada (K.S.J.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (M.A.O.); and Department of Radiology, Zuckerberg San Francisco General Hospital, San Francisco, Calif (M.A.O.).ORCID 0000-0003-0563-542X
Octavia BaneFrom the BioMedical Engineering and Imaging Institute (E.O., P.K., O.B., B.T.) and Departments of Diagnostic, Molecular and Interventional Radiology (E.O., P.K., O.B., B.T.) Environmental Medicine and Public Health (J.T.D.), Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029; Department of Radiology, Mayo Clinic, Rochester, Minn (J.C., P.J.R., S.K.V., R.L.E.); Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China (J.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D., J.A.T.); Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women's College Hospital, University of Toronto, Toronto, Canada (K.S.J.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (M.A.O.); and Department of Radiology, Zuckerberg San Francisco General Hospital, San Francisco, Calif (M.A.O.).
Jonathan R DillmanFrom the BioMedical Engineering and Imaging Institute (E.O., P.K., O.B., B.T.) and Departments of Diagnostic, Molecular and Interventional Radiology (E.O., P.K., O.B., B.T.) Environmental Medicine and Public Health (J.T.D.), Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029; Department of Radiology, Mayo Clinic, Rochester, Minn (J.C., P.J.R., S.K.V., R.L.E.); Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China (J.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D., J.A.T.); Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women's College Hospital, University of Toronto, Toronto, Canada (K.S.J.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (M.A.O.); and Department of Radiology, Zuckerberg San Francisco General Hospital, San Francisco, Calif (M.A.O.).ORCID 0000-0003-0124-0164
Kartik S JhaveriFrom the BioMedical Engineering and Imaging Institute (E.O., P.K., O.B., B.T.) and Departments of Diagnostic, Molecular and Interventional Radiology (E.O., P.K., O.B., B.T.) Environmental Medicine and Public Health (J.T.D.), Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029; Department of Radiology, Mayo Clinic, Rochester, Minn (J.C., P.J.R., S.K.V., R.L.E.); Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China (J.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D., J.A.T.); Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women's College Hospital, University of Toronto, Toronto, Canada (K.S.J.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (M.A.O.); and Department of Radiology, Zuckerberg San Francisco General Hospital, San Francisco, Calif (M.A.O.).ORCID 0000-0003-0938-0321
Michael A OhligerFrom the BioMedical Engineering and Imaging Institute (E.O., P.K., O.B., B.T.) and Departments of Diagnostic, Molecular and Interventional Radiology (E.O., P.K., O.B., B.T.) Environmental Medicine and Public Health (J.T.D.), Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029; Department of Radiology, Mayo Clinic, Rochester, Minn (J.C., P.J.R., S.K.V., R.L.E.); Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China (J.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D., J.A.T.); Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women's College Hospital, University of Toronto, Toronto, Canada (K.S.J.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (M.A.O.); and Department of Radiology, Zuckerberg San Francisco General Hospital, San Francisco, Calif (M.A.O.).ORCID 0000-0001-6878-8189
Phillip J RossmanFrom the BioMedical Engineering and Imaging Institute (E.O., P.K., O.B., B.T.) and Departments of Diagnostic, Molecular and Interventional Radiology (E.O., P.K., O.B., B.T.) Environmental Medicine and Public Health (J.T.D.), Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029; Department of Radiology, Mayo Clinic, Rochester, Minn (J.C., P.J.R., S.K.V., R.L.E.); Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China (J.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D., J.A.T.); Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women's College Hospital, University of Toronto, Toronto, Canada (K.S.J.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (M.A.O.); and Department of Radiology, Zuckerberg San Francisco General Hospital, San Francisco, Calif (M.A.O.).ORCID 0000-0002-3245-4934
Jean A TkachFrom the BioMedical Engineering and Imaging Institute (E.O., P.K., O.B., B.T.) and Departments of Diagnostic, Molecular and Interventional Radiology (E.O., P.K., O.B., B.T.) Environmental Medicine and Public Health (J.T.D.), Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029; Department of Radiology, Mayo Clinic, Rochester, Minn (J.C., P.J.R., S.K.V., R.L.E.); Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China (J.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D., J.A.T.); Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women's College Hospital, University of Toronto, Toronto, Canada (K.S.J.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (M.A.O.); and Department of Radiology, Zuckerberg San Francisco General Hospital, San Francisco, Calif (M.A.O.).
John T DoucetteFrom the BioMedical Engineering and Imaging Institute (E.O., P.K., O.B., B.T.) and Departments of Diagnostic, Molecular and Interventional Radiology (E.O., P.K., O.B., B.T.) Environmental Medicine and Public Health (J.T.D.), Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029; Department of Radiology, Mayo Clinic, Rochester, Minn (J.C., P.J.R., S.K.V., R.L.E.); Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China (J.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D., J.A.T.); Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women's College Hospital, University of Toronto, Toronto, Canada (K.S.J.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (M.A.O.); and Department of Radiology, Zuckerberg San Francisco General Hospital, San Francisco, Calif (M.A.O.).ORCID 0000-0001-8985-0367
Sudhakar K VenkateshFrom the BioMedical Engineering and Imaging Institute (E.O., P.K., O.B., B.T.) and Departments of Diagnostic, Molecular and Interventional Radiology (E.O., P.K., O.B., B.T.) Environmental Medicine and Public Health (J.T.D.), Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029; Department of Radiology, Mayo Clinic, Rochester, Minn (J.C., P.J.R., S.K.V., R.L.E.); Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China (J.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D., J.A.T.); Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women's College Hospital, University of Toronto, Toronto, Canada (K.S.J.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (M.A.O.); and Department of Radiology, Zuckerberg San Francisco General Hospital, San Francisco, Calif (M.A.O.).ORCID 0000-0002-7514-1030
Richard L EhmanFrom the BioMedical Engineering and Imaging Institute (E.O., P.K., O.B., B.T.) and Departments of Diagnostic, Molecular and Interventional Radiology (E.O., P.K., O.B., B.T.) Environmental Medicine and Public Health (J.T.D.), Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029; Department of Radiology, Mayo Clinic, Rochester, Minn (J.C., P.J.R., S.K.V., R.L.E.); Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China (J.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D., J.A.T.); Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women's College Hospital, University of Toronto, Toronto, Canada (K.S.J.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (M.A.O.); and Department of Radiology, Zuckerberg San Francisco General Hospital, San Francisco, Calif (M.A.O.).ORCID 0000-0001-7041-5074
Bachir TaouliFrom the BioMedical Engineering and Imaging Institute (E.O., P.K., O.B., B.T.) and Departments of Diagnostic, Molecular and Interventional Radiology (E.O., P.K., O.B., B.T.) Environmental Medicine and Public Health (J.T.D.), Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029; Department of Radiology, Mayo Clinic, Rochester, Minn (J.C., P.J.R., S.K.V., R.L.E.); Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China (J.C.); Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D., J.A.T.); Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women's College Hospital, University of Toronto, Toronto, Canada (K.S.J.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (M.A.O.); and Department of Radiology, Zuckerberg San Francisco General Hospital, San Francisco, Calif (M.A.O.).ORCID 0000-0001-6409-1333

Funding

Magnetic Resonance ElastographyR37EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2016 to 2025
$4.0M
Prediction of portal pressure with liver and spleen MR Elastography and 4D flow phase-contrast MRIR01DK113272 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TAOULI, BACHIR · 2018 to 2021
$2.0M
NIBIB NIH HHS R37 EB001981NIDDK NIH HHS R01 DK113272
6 · The paper itself

Abstract

Background MR elastography (MRE) has been shown to have excellent performance for noninvasive liver fibrosis staging. However, there is limited knowledge regarding the precision and test-retest repeatability of stiffness measurement with MRE in the multicenter setting. Purpose To determine the precision and test-retest repeatability of stiffness measurement with MRE across multiple centers using the same phantoms. Materials and Methods In this study, three cylindrical phantoms made of polyvinyl chloride gel mimicking different degrees of liver stiffness in humans (phantoms 1-3: soft, medium, and hard stiffness, respectively) were evaluated. Between January 2021 and January 2022, phantoms were circulated between five different centers and scanned with 10 MRE-equipped clinical 1.5-T and 3-T systems from three major vendors, using two-dimensional (2D) gradient-recalled echo (GRE) imaging and/or 2D spin-echo (SE) echo-planar imaging (EPI). Similar MRE acquisition parameters, hardware, and reconstruction algorithms were used at each center. Mean stiffness was measured by a single observer for each phantom and acquisition on a single section. Stiffness measurement precision and same-session test-retest repeatability were assessed using the coefficient of variation (CV) and the repeatability coefficient (RC), respectively. Results The mean precision represented by the CV was 5.8% (95% CI: 3.8, 7.7) for all phantoms and both sequences combined. For all phantoms, 2D GRE achieved a CV of 4.5% (95% CI: 3.3, 5.7) whereas 2D SE EPI achieved a CV of 7.8% (95% CI: 3.1, 12.6). The mean RC of stiffness measurement was 5.8% (95% CI: 3.7, 7.8) for all phantoms and both sequences combined, 4.9% (95% CI: 2.7, 7.0) for 2D GRE, and 7.0% (95% CI: 2.9, 11.2) for 2D SE EPI (all phantoms). Conclusion MRE had excellent in vitro precision and same-session test-retest repeatability in the multicenter setting when similar imaging protocols, hardware, and reconstruction algorithms were used. © RSNA, 2024

Indexed as

Elasticity Imaging TechniquesPhantoms, ImagingHumansLiverLiver CirrhosisMagnetic Resonance ImagingReproducibility of Results

Identifiers

PMID38742971
PMCPMC11140535

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