Evidence map›Paper›PMID 38742969›Full record

ArticleRadiology2024

Cerebellar Mutism Syndrome and Dentato-Thalamo-Cortical Tract Disruption in Diffusion Tractography Following Surgery for Medulloblastoma.

Qing Ji, Samuel S McAfee, Matthew Scoggins, Joseph Holtrop, John O Glass, Xiaomeng Yuan, Jia Liang, Yimei Li, Jason Chiang, Brent A Orr and 9 more

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In one paragraph

Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Multimodal Imaging Investigation of the Dentato-Thalamo-Cortical Pathway in Friedreich's Ataxia.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Qing JiFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
Samuel S McAfeeFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
Matthew ScogginsFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.ORCID 0000-0003-1783-4274
Joseph HoltropFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
John O GlassFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
Xiaomeng YuanFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
Jia LiangFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
Yimei LiFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
Jason ChiangFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
Brent A OrrFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
Angela EdwardsFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
Diana StormentFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
Tara BrinkmanFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
Giles W RobinsonFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
Amar GajjarFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
Wilburn E ReddickFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.ORCID 0000-0002-1054-1201
Zoltán PatayFrom the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
Raja B Khan *From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
Asim K Bag *From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.ORCID 0000-0001-6164-5863

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Cerebellar mutism syndrome (CMS), a complication following medulloblastoma surgery, has been linked to dentato-thalamo-cortical tract (DTCT) injury; the association of the degree of DTCT injury with severity of CMS-related symptoms has not been investigated. Purpose To investigate the association between severity of CMS-related symptoms and degree and patterns of DTCT injury with use of diffusion tensor imaging (DTI), and if laterality of injury influences neurologic symptoms. Materials and Methods This retrospective case-control study used prospectively collected clinical and DTI data on patients with medulloblastoma enrolled in a clinical trial (between July 2016 and February 2020) and healthy controls (between April and November 2017), matched with the age range of the participants with medulloblastoma. CMS was divided into types 1 (CMS1) and 2 (CMS2). Multivariable logistic regression was used to investigate the relationship between CMS likelihood and DTCT injury. Results Overall, 82 participants with medulloblastoma (mean age, 11.0 years ± 5.2 [SD]; 53 male) and 35 healthy controls (mean age, 18.0 years ± 3.06; 18 female) were included. In participants with medulloblastoma, DTCT was absent bilaterally (AB), absent on the right side (AR), absent on the left side (AL), or present bilaterally (PB), while it was PB in all healthy controls. Odds of having CMS were associated with higher degree of DTCT damage (AB, odds ratio = 272.7 [95% CI: 269.68, 275.75;

Indexed as

Cerebellar NeoplasmsDiffusion Tensor ImagingMedulloblastomaMutismPostoperative ComplicationsAdolescentCase-Control StudiesChildFemaleHumansMaleNeural PathwaysRetrospective StudiesThalamus

Identifiers

PMID38742969
PMCPMC11140529

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.