Evidence map›Paper›PMID 38742942›Full record

ArticleAging2024

IL27 and IL1RN are causally associated with acute pancreatitis: a Mendelian randomization study.

Qingxu Jing, Xuxu Liu, Zhenyi Lv, Dongbo Xue

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Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Qingxu JingDepartment of General Surgery, The First Affiliated Hospital of Harbin Medical, University, Harbin 150001, China.
Xuxu LiuDepartment of General Surgery, The First Affiliated Hospital of Harbin Medical, University, Harbin 150001, China.
Zhenyi LvDepartment of General Surgery, The First Affiliated Hospital of Harbin Medical, University, Harbin 150001, China.
Dongbo XueDepartment of General Surgery, The First Affiliated Hospital of Harbin Medical, University, Harbin 150001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe interleukin (IL) plays a role in the development of acute pancreatitis (AP). However, the specific IL in AP has not been fully revealed. Therefore, the association between prospective IL and AP was studied via Mendelian randomization (MR).

methodsThe HUGO Gene nomenclature committee (HGNC) database provided 47 interleukin related genes (ILRGs). ILRGs and differentially expressed genes (DEGs) from GSE194331 were overlapped to create differently expressed ILRGs (DE-ILRGs). The integrative epidemiology unit (IEU) open genome-wide association study (GWAS) database provided exposure and outcome datasets. Univariate MR (UVMR) analysis using MR-Egger, IVW, simple mode, and weighted mode was done. UVMR results were verified using sensitivity analysis. Drug prediction, MVMR analysis, and PPI network development were also performed.

resultsSix DE-ILRGs were obtained. IL27 and IL1RN were substantially causally linked with AP by UVMR analysis (OR = 0.926, P < 0.001 and OR = 1.031, P = 0.023). Our sensitivity analysis showed the dependability of our results. Direct effect of IL27 was suggested by MVMR analysis. In the cytokine receptor binding pathway, IL27 and IL1RN interacted with IL36G and IL1R2. TAE-684, ARQ-680, and 12 other IL1RN and 14 IL27 medications were predicted.

conclusionsIL1RN was identified as a risk factor for acute pancreatitis (AP), but IL27 was found to be a protective factor for AP.

Indexed as

Interleukin 1 Receptor Antagonist ProteinMendelian Randomization AnalysisPancreatitisGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInterleukinsPolymorphism, Single NucleotideIL1RN protein, humanInterleukin 1 Receptor Antagonist ProteinInterleukinsMYDGF protein, humanacute pancreatitisIL1RNIL27interleukinsMendelian randomization

Identifiers

PMID38742942
PMCPMC11164491

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.