ArticleAging cell2024
Age-related dysregulation of the retinal transcriptome in African turquoise killifish.
Article in Aging cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Long read sequencing of retinal RNA improves killifish transcriptome annotation.bioRxiv : the preprint server for biology · 2026Article
- Ordered Chaos: Photoreceptor Mosaics in the Larval and Adult Turquoise Killifish (Nothobranchius furzeri).The Journal of comparative neurology · 2026Article
- The extreme diversity of retinal amacrine cells has deep evolutionary roots.Science advances · 2026Article
- Developing species-specific welfare scoresheets for the African Turquoise Killifish.Scientific reports · 2026Article
- A single-cell RNA sequencing dataset of cardiac aging in African Turquoise Killifish.Scientific data · 2026Article
- The Extreme Diversity Of Retinal Amacrine Cells Has Deep Evolutionary Roots.bioRxiv : the preprint server for biology · 2026Article
- Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish.Nature aging · 2026Article
- Fibrotic scarring prevents optic nerve regeneration despite preserved axonal growth potential in adult killifish.Frontiers in neuroscience · 2026Article
- Successful axonal regeneration is associated with intraneuronal metabolic reprogramming.iScience · 2025Article
- Differential retinal ganglion cell resilience to optic nerve injury across vertebrate species.Frontiers in neuroscience · 2025Article
- 'Iterative Bleaching Extends Multiplexity' facilitates simultaneous identification of all major retinal cell types.Journal of cell science · 2024Article
- Age-related dysregulation of the retinal transcriptome in African turquoise killifish.Aging cell · 2024Article
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Abstract
Age-related vision loss caused by retinal neurodegenerative pathologies is becoming more prevalent in our ageing society. To understand the physiological and molecular impact of ageing on retinal homeostasis, we used the short-lived African turquoise killifish, a model known to naturally develop central nervous system (CNS) ageing hallmarks and vision loss. Bulk and single-cell RNA-sequencing (scRNAseq) of three age groups (6-, 12-, and 18-week-old) identified transcriptional ageing fingerprints in the killifish retina, unveiling pathways also identified in the aged brain, including oxidative stress, gliosis, and inflammageing. These findings were comparable to observations in the ageing mouse retina. Additionally, transcriptional changes in genes related to retinal diseases, such as glaucoma and age-related macular degeneration, were observed. The cellular heterogeneity in the killifish retina was characterized, confirming the presence of all typical vertebrate retinal cell types. Data integration from age-matched samples between the bulk and scRNAseq experiments revealed a loss of cellular specificity in gene expression upon ageing, suggesting potential disruption in transcriptional homeostasis. Differential expression analysis within the identified cell types highlighted the role of glial/immune cells as important stress regulators during ageing. Our work emphasizes the value of the fast-ageing killifish in elucidating molecular signatures in age-associated retinal disease and vision decline. This study contributes to the understanding of how age-related changes in molecular pathways may impact CNS health, providing insights that may inform future therapeutic strategies for age-related pathologies.
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