Evidence map›Paper›PMID 38742887›Full record

ArticlemSphere2024

A shared group of bacterial taxa in the duodenal microbiota of undernourished Pakistani children with environmental enteric dysfunction.

Najeeha T Iqbal, Robert Y Chen, Nicholas W Griffin, Matthew C Hibberd, Aqsa Khalid, Kamran Sadiq, Zehra Jamil, Kumail Ahmed, Junaid Iqbal, Aneeta Hotwani and 12 more

Abstract read
In one paragraph

Article in mSphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Najeeha T IqbalDepartment of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Robert Y ChenThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Nicholas W GriffinThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Matthew C HibberdThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Aqsa KhalidDepartment of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Kamran SadiqDepartment of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Zehra JamilDepartment of Biological and Biomedical Sciences, Aga Khan University Hospital, Karachi, Pakistan.
Kumail AhmedDepartment of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Junaid IqbalDepartment of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Aneeta HotwaniDepartment of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Furqan KabirDepartment of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Najeeb RahmanDepartment of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Arjumand RizviDepartment of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Romana IdressDepartment of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan.
Zubair AhmedDepartment of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan.
Sheraz AhmedDepartment of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Fayaz UmraniDepartment of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Sana SyedDepartment of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Sean R MooreDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0003-1150-6632
Asad AliDepartment of Paediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.ORCID 0000-0001-5274-7665
Michael J BarrattThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Jeffrey I GordonThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0001-8304-3548

Funding

Microbiota, Inflammation and Environmental Enteric Dysfunction (MiEED)K43TW010697 · FIC · AGA KHAN UNIVERSITY (PAKISTAN) · PI IQBAL, NAJEEHA TALAT · 2017 to 2019
$185k
Bill and Melinda Gates Foundation (GF) OPP1138727Bill and Melinda Gates Foundation (GF) OPP1144149FIC NIH HHS K43 TW010697
6 · The paper itself

Abstract

Environmental enteric dysfunction (EED) is a subclinical syndrome of altered small intestinal function postulated to be an important contributor to childhood undernutrition. The role of small intestinal bacterial communities in the pathophysiology of EED is poorly defined due to a paucity of studies where there has been a direct collection of small intestinal samples from undernourished children. Sixty-three members of a Pakistani cohort identified as being acutely malnourished between 3 and 6 months of age and whose wasting (weight-for-length

Indexed as

BacteriaDuodenumGastrointestinal MicrobiomeRNA, Ribosomal, 16SChild, PreschoolCohort StudiesFecesFemaleHumansInfantMaleMalnutritionPakistanRNA, Ribosomal, 16Schildhood undernutritionpathogenesis of environmental enteric dysfunctionsmall intestinal microbiota

Identifiers

PMID38742887
PMCPMC11332341

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.