Evidence map›Paper›PMID 38742830›Full record

ArticlemBio2024

Key aspects of papillomavirus infection influence the host cervicovaginal microbiome in a preclinical murine papillomavirus (MmuPV1) infection model.

Megan E Spurgeon, Elizabeth C Townsend, Simon Blaine-Sauer, Stephanie M McGregor, Mark Horswill, Johan A den Boon, Paul Ahlquist, Lindsay Kalan, Paul F Lambert

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Megan E Spurgeon *McArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-9753-6615
Elizabeth C Townsend *Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-3102-8033
Simon Blaine-SauerMcArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-6027-1409
Stephanie M McGregorDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Mark HorswillMcArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Johan A den BoonMcArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-5507-917X
Paul AhlquistMcArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-4584-9318
Lindsay KalanDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-4980-5128
Paul F LambertMcArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-7983-2755

Funding

Visualizing EBV and HCMV DNA Dynamics During InfectionP01CA022443 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Paul F. Lambert · 1985 to 2026
$53.1M
Defining Drivers of HPV-associated CarcinogenesisR35CA210807 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Paul F. Lambert · 2017 to 2026
$9.2M
Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Elucidating the Role of Microbial Community Dynamics in Wound Repair and RegenerationR35GM137828 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KALAN, LINDSAY ROBYN · 2020 to 2021
$750k
Small DNA Tumor Viruses and Human CancerR50CA211246 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SPURGEON, MEGAN E · 2016 to 2020
$644k
HHS | National Institutes of Health (NIH) R35GM137828HHS | NIH | National Cancer Institute (NCI) P01CA022443, R35CA210807HHS | NIH | National Cancer Institute (NCI) R50CA211246Mary Kay Ash Foundation (MKF) 09-20NCI NIH HHS P01 CA022443NCI NIH HHS R35 CA210807NCI NIH HHS R50 CA211246NIGMS NIH HHS R35 GM137828
6 · The paper itself

Abstract

Human papillomaviruses (HPVs) are the most common sexually transmitted infection in the United States and are a major etiological agent of cancers in the anogenital tract and oral cavity. Growing evidence suggests changes in the host microbiome are associated with the natural history and ultimate outcome of HPV infection. We sought to define changes in the host cervicovaginal microbiome during papillomavirus infection, persistence, and pathogenesis using the murine papillomavirus (MmuPV1) cervicovaginal infection model. Cervicovaginal lavages were performed over a time course of MmuPV1 infection in immunocompetent female

Indexed as

Cervix UteriDisease Models, AnimalMicrobiotaPapillomaviridaePapillomavirus InfectionsRNA, Ribosomal, 16SVaginaAnimalsFemaleMiceViral LoadRNA, Ribosomal, 16Scervixmicrobiomemouse papillomavirusMus musculuspapillomavirusvagina

Identifiers

PMID38742830
PMCPMC11237646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.