Evidence map›Paper›PMID 38742491›Full record

Observational studyCirculation2024

Influence of Pathophysiologic Patterns of Coronary Artery Disease on Immediate Percutaneous Coronary Intervention Outcomes.

Carlos Collet, Daniel Munhoz, Takuya Mizukami, Jeroen Sonck, Hitoshi Matsuo, Toshiro Shinke, Hirohiko Ando, Brian Ko, Simone Biscaglia, Fernando Rivero and 33 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04789317 (Pullback Pressure Gradient), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04789317 active not recruitingnot on this map

Pullback Pressure Gradient (PPG) Global Registry: Prospective Evaluation of the Impact of the PPG Index on Clinical Decision Making and Outcomes

Typeobservational_patient_registrySponsorVZW Cardiovascular Research Center AalstRan2020 to 2026Enrolled982ConditionsChronic Coronary Insufficiency, Non ST Elevation Myocardial Infarction
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Article
  9. Influence of Pullback Pressure Gradient on Residual Angina at One Year.Circulation. Cardiovascular interventions · 2026
    Article
  10. Article
  11. Review
  12. Sex Differences in Atherosclerotic Coronary Artery Disease Patterns.Journal of the American Heart Association · 2025
    Article
  13. Review
  14. Novel Non-Hyperemic Coronary Physiology Indices for Vessel Longitudinal Analysis.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025
    Observational
  15. Article
  16. Review
  17. Review
  18. [Application advances of fractional flow reserve in endovascular treatment of lower-extremity arterial disease].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  19. Validation of the pullback pressure gradient in resting conditions.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025
    Article
  20. Intracoronary nicardipine to induce hyperaemia.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

43 authors.

Carlos ColletCardiovascular Center Aalst, OLV Clinic, Aalst, Belgium (C.C., D.M., T.M., J.S., K.S., T. Storozhenko, T.D.P., W.H., D.B., J.B., B.D.B.).ORCID 0000-0003-0227-0082
Daniel MunhozCardiovascular Center Aalst, OLV Clinic, Aalst, Belgium (C.C., D.M., T.M., J.S., K.S., T. Storozhenko, T.D.P., W.H., D.B., J.B., B.D.B.).ORCID 0000-0002-8951-4504
Takuya MizukamiCardiovascular Center Aalst, OLV Clinic, Aalst, Belgium (C.C., D.M., T.M., J.S., K.S., T. Storozhenko, T.D.P., W.H., D.B., J.B., B.D.B.).ORCID 0000-0003-1086-8746
Jeroen SonckCardiovascular Center Aalst, OLV Clinic, Aalst, Belgium (C.C., D.M., T.M., J.S., K.S., T. Storozhenko, T.D.P., W.H., D.B., J.B., B.D.B.).ORCID 0000-0002-9744-8244
Hitoshi MatsuoDepartment of Cardiovascular Medicine, Gifu Heart Center, Japan (H.M.).ORCID 0000-0002-1571-6533
Toshiro ShinkeDepartment of Medicine, Division of Cardiology, Showa University School of Medicine, Tokyo, Japan (T. Shinke, K.S.).ORCID 0000-0001-7349-7538
Hirohiko AndoDepartment of Cardiology, Aichi Medical University, Japan (H.A., T.A.).
Brian KoMonash Cardiovascular Research Centre, Monash University and Monash Heart, Monash Health, Clayton, Victoria, Australia (B.K.).ORCID 0000-0002-0089-3676
Simone BiscagliaCardiology Unit, Azienda Ospedaliera Universitaria di Ferrara, Italy (S.B., G.C.).
Fernando RiveroCardiac Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain (F.R.).ORCID 0000-0002-3676-0277
Thomas EngstrømRigshospitalet, University of Copenhagen, Denmark (T.E., K.A.).ORCID 0000-0001-5436-9194
Ketina ArslaniRigshospitalet, University of Copenhagen, Denmark (T.E., K.A.).
Antonio Maria LeoneDepartment of Cardiovascular Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (A.M.L.).ORCID 0000-0002-1276-9883
Lokien X van NunenDepartment of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands (L.X.v.N.).ORCID 0000-0003-4650-5381
William F FearonDivision of Cardiovascular Medicine and Stanford Cardiovascular Institute, Stanford University School of Medicine and VA Palo Alto Health Care System, Palo Alto, CA (W.F.F.).ORCID 0000-0003-1799-1368
Evald Høj ChristiansenDepartment of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark (E.H.C.).ORCID 0000-0002-8740-4862
Stephane FournierDepartment of Cardiology, University Hospital of Lausanne, Switzerland (S.F., B.D.B.).
Liyew DestaDepartment of Cardiology, Karolinska University Hospital, Solna, Stockholm, Sweden (L.D.).
Andy YongConcord Repatriation General Hospital, University of Sydney, New South Wales, Australia (A.Y.).ORCID 0000-0002-6268-4300
Julien AdjedjDepartment of Cardiology, Arnault Tzanck Institute Saint Laurent du Var, France (J.A.).
Javier EscanedInstituto de Investigacion Sanitaria del Hospital Clinico San Carlos and Complutense University, Madrid, Spain (J.E.).ORCID 0000-0003-4932-0112
Masafumi NakayamaDepartment of Cardiology, Tokyo D Tower Hospital, Japan (M.N.).ORCID 0000-0001-8024-9620
Ashkan EftekhariDepartment of Cardiology, Aalborg University Hospital, Denmark (A.E.).
Frederik M ZimmermannDepartment of Cardiology, Catharina Hospital Eindhoven, the Netherlands (F.M.Z., N.H.J.P.).
Koshiro SakaiCardiovascular Center Aalst, OLV Clinic, Aalst, Belgium (C.C., D.M., T.M., J.S., K.S., T. Storozhenko, T.D.P., W.H., D.B., J.B., B.D.B.).ORCID 0000-0003-0461-6497
Tatyana StorozhenkoCardiovascular Center Aalst, OLV Clinic, Aalst, Belgium (C.C., D.M., T.M., J.S., K.S., T. Storozhenko, T.D.P., W.H., D.B., J.B., B.D.B.).ORCID 0000-0002-9158-2012
Bruno R da CostaClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, UK (B.R.d.C.).ORCID 0000-0002-1786-6332
Gianluca CampoCardiology Unit, Azienda Ospedaliera Universitaria di Ferrara, Italy (S.B., G.C.).ORCID 0000-0002-5150-188X
Nick E J WestAbbott Vascular, Santa Clara, CA (N.E.J.W.).ORCID 0000-0003-2966-6562
Tom De PotterCardiovascular Center Aalst, OLV Clinic, Aalst, Belgium (C.C., D.M., T.M., J.S., K.S., T. Storozhenko, T.D.P., W.H., D.B., J.B., B.D.B.).ORCID 0000-0003-1424-114X
Ward HeggermontCardiovascular Center Aalst, OLV Clinic, Aalst, Belgium (C.C., D.M., T.M., J.S., K.S., T. Storozhenko, T.D.P., W.H., D.B., J.B., B.D.B.).ORCID 0000-0002-5368-2223
Dimitri BuytaertCardiovascular Center Aalst, OLV Clinic, Aalst, Belgium (C.C., D.M., T.M., J.S., K.S., T. Storozhenko, T.D.P., W.H., D.B., J.B., B.D.B.).
Jozef BartunekCardiovascular Center Aalst, OLV Clinic, Aalst, Belgium (C.C., D.M., T.M., J.S., K.S., T. Storozhenko, T.D.P., W.H., D.B., J.B., B.D.B.).ORCID 0000-0002-4927-1632
Colin BerrySchool of Cardiovascular and Metabolic Health, University of Glasgow, UK (C.B., D.C.).ORCID 0000-0002-4547-8636
Damien CollisonSchool of Cardiovascular and Metabolic Health, University of Glasgow, UK (C.B., D.C.).ORCID 0000-0002-3531-0872
Thomas JohnsonUniversity Hospitals Bristol & Weston NHS Foundation Trust, Bristol, UK (T.J.).
Tetsuya AmanoDepartment of Cardiology, Aichi Medical University, Japan (H.A., T.A.).ORCID 0000-0002-6833-3675
Divaka PereraSchool of Cardiovascular Medicine and Sciences, St Thomas' Hospital Campus, King's College London, UK (D.P.).ORCID 0000-0001-6362-1291
Allen JeremiasSt Francis Hospital and Heart Center, Roslyn, NY (A.J., Z.A.).ORCID 0000-0003-2328-4686
Ziad AliSt Francis Hospital and Heart Center, Roslyn, NY (A.J., Z.A.).ORCID 0000-0002-2482-3197
Nico H J PijlsDepartment of Cardiology, Catharina Hospital Eindhoven, the Netherlands (F.M.Z., N.H.J.P.).ORCID 0000-0001-5863-6966
Bernard De BruyneCardiovascular Center Aalst, OLV Clinic, Aalst, Belgium (C.C., D.M., T.M., J.S., K.S., T. Storozhenko, T.D.P., W.H., D.B., J.B., B.D.B.).ORCID 0000-0001-6567-168X
Nils P JohnsonWeatherhead PET Center, Division of Cardiology, Department of Medicine, McGovern Medical School at UTHealth and Memorial Hermann Hospital, Houston, TX (N.P.J.).ORCID 0000-0002-0897-2301

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiffuse coronary artery disease affects the safety and efficacy of percutaneous coronary intervention (PCI). Pathophysiologic coronary artery disease patterns can be quantified using fractional flow reserve (FFR) pullbacks incorporating the pullback pressure gradient (PPG) calculation. This study aimed to establish the capacity of PPG to predict optimal revascularization and procedural outcomes.

methodsThis prospective, investigator-initiated, single-arm, multicenter study enrolled patients with at least one epicardial lesion with an FFR ≤0.80 scheduled for PCI. Manual FFR pullbacks were used to calculate PPG. The primary outcome of optimal revascularization was defined as an FFR ≥0.88 after PCI.

resultsA total of 993 patients with 1044 vessels were included. The mean FFR was 0.68±0.12, PPG 0.62±0.17, and the post-PCI FFR was 0.87±0.07. PPG was significantly correlated with the change in FFR after PCI (r=0.65 [95% CI, 0.61-0.69];

conclusionsPathophysiologic coronary artery disease patterns distinctly affect the safety and effectiveness of PCI. PPG showed an excellent predictive capacity for optimal revascularization and demonstrated added value compared with an FFR measurement. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04789317.

Indexed as

Coronary Artery DiseaseFractional Flow Reserve, MyocardialPercutaneous Coronary InterventionAgedFemaleHumansMaleMiddle AgedProspective StudiesTreatment Outcomecoronary artery diseasehemodynamicspercutaneous coronary intervention

Identifiers

PMID38742491
PMCPMC11335079

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.