Evidence map›Paper›PMID 38742428›Full record

ArticleCirculation. Heart failure2024

Risk Factors and Outcomes Associated With Heart Failure With Preserved and Reduced Ejection Fraction in People With Chronic Kidney Disease.

Nisha Bansal, Leila R Zelnick, Rebecca Scherzer, Michelle Estrella, Michael G Shlipak

Abstract read
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Article in Circulation. Heart failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  4. Update on clinical heart failure trials.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Nisha BansalDivision of Nephrology, University of Washington, Seattle (N.B., L.Z.).ORCID 0000-0002-9583-8628
Leila R ZelnickDivision of Nephrology, University of Washington, Seattle (N.B., L.Z.).ORCID 0000-0002-8461-5111
Rebecca ScherzerKidney Health Research Collaborative, University of California, San Francisco (R.S., M.E., M.S.).ORCID 0000-0002-1579-5390
Michelle EstrellaKidney Health Research Collaborative, University of California, San Francisco (R.S., M.E., M.S.).ORCID 0000-0002-8902-9576
Michael G ShlipakKidney Health Research Collaborative, University of California, San Francisco (R.S., M.E., M.S.).ORCID 0000-0002-9559-204X

Funding

Kidney Injury in Patients with Acute Decompensated Heart FailureR01DK121800 · NIDDK · UNIVERSITY OF WASHINGTON · PI BANSAL, NISHA · 2020 to 2024
$3.2M
Heart failure and atrial arrhythmias in CKDR01DK103612 · NIDDK · UNIVERSITY OF WASHINGTON · PI BANSAL, NISHA · 2015 to 2018
$1.9M
Mentored research in the intersection of kidney and cardiovascular diseaseK26DK138333 · NIDDK · UNIVERSITY OF WASHINGTON · PI Nisha Bansal · 2023 to 2026
$440k
NIDDK NIH HHS K26 DK138333NIDDK NIH HHS R01 DK103612NIDDK NIH HHS R01 DK121800
6 · The paper itself

Abstract

backgroundHeart failure (HF) is associated with poor outcomes in people with chronic kidney disease, yet it is unknown whether outcomes differ by HF subtype. This study aimed to examine associations of incident HF with preserved ejection fraction (HFpEF) versus HF with reduced ejection fraction (HFrEF) with progression to end-stage kidney disease (ESKD) and mortality.

methodsWe studied individuals with chronic kidney disease in the CRIC study (Chronic Renal Insufficiency Cohort) who were free of HF at cohort entry. Incident HF hospitalizations were adjudicated and classified into HFpEF (ejection fraction, ≥50%) or HFrEF (ejection fraction, <50%) based on echocardiograms performed during the hospitalization or at a research study visit. ESKD was defined as need for chronic dialysis or kidney transplant. Cox proportional hazards were used to evaluate the association of time-updated HF subtype with risk of ESKD and mortality, adjusting for demographics, comorbidities, and medication use.

resultsAmong the 3557 study participants without HF at cohort entry, mean age was 57 years and mean estimated glomerular filtration rate was 45 mL/min per 1.73 m

conclusionsIn a chronic kidney disease population, the rates of HFpEF hospitalizations were greater than that of HFrEF. Risk of ESKD was high but not statically different across HF subtypes. There was a stronger association of HFrEF with mortality. Prevention and treatment of both HFpEF and HFrEF should be central priorities to improve outcomes in chronic kidney disease.

Indexed as

Heart FailureRenal Insufficiency, ChronicStroke VolumeAgedDisease ProgressionFemaleGlomerular Filtration RateHospitalizationHumansIncidenceKidney Failure, ChronicMaleMiddle AgedRisk Factorsblood pressurechronic kidney diseaseheart failurerisk factorsstroke

Identifiers

PMID38742428
PMCPMC11108746

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.