Evidence map›Paper›PMID 38742231›Full record

ArticleFrontiers in toxicology2024

New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project.

Tamara Tal, Oddvar Myhre, Ellen Fritsche, Joëlle Rüegg, Kai Craenen, Kiara Aiello-Holden, Caroline Agrillo, Patrick J Babin, Beate I Escher, Hubert Dirven and 24 more

Abstract read
In one paragraph

Article in Frontiers in toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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  13. TheToxicology reports · 2025
    Article
  14. Advances in Cytotoxicity Testing: From In Vitro Assays to In Silico Models.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Tamara TalHelmholtz Centre for Environmental Research - UFZ, Chemicals in the Environment Research Section, Leipzig, Germany.
Oddvar MyhreNorwegian Institute of Public Health - NIPH, Department of Chemical Toxicology, Oslo, Norway.
Ellen FritscheIUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
Joëlle RüeggUppsala University, Department of Organismal Biology, Uppsala, Sweden.
Kai CraenenEuropean Chemicals Agency (ECHA), Helsinki, Finland.
Kiara Aiello-HoldenGerman Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Caroline AgrilloUppsala University, Department of Organismal Biology, Uppsala, Sweden.
Patrick J BabinUniversité de Bordeaux, Institut National de la Santé et de la Recherche Médicale (INSERM), Maladies Rares: Génétique et Métabolisme (MRGM), Pessac, France.
Beate I EscherHelmholtz Centre for Environmental Research - UFZ, Chemicals in the Environment Research Section, Leipzig, Germany.
Hubert DirvenNorwegian Institute of Public Health - NIPH, Department of Chemical Toxicology, Oslo, Norway.
Kati HellstenEuropean Chemicals Agency (ECHA), Helsinki, Finland.
Kristine DolvaUniversity of Oslo, Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, Olso, Norway.
Ellen HesselDutch Nation Institute for Public Health and the Environment (RIVM), Centre for Health Protection, Bilthoven, Netherlands.
Harm J HeusinkveldDutch Nation Institute for Public Health and the Environment (RIVM), Centre for Health Protection, Bilthoven, Netherlands.
Yavor HadzhievUniversity of Birmingham, Centre for Environmental Research and Justice, Birmingham, UK.
Selma HuremNorwegian University of Life Sciences (NMBU), Faculty of Veterinary Medicine, Ås, Norway.
Karolina JagielloUniversity of Gdansk, Laboratory of Environmental Chemoinformatics, Gdansk, Poland.
Beata JudzinskaUniversity of Gdansk, Laboratory of Environmental Chemoinformatics, Gdansk, Poland.
Nils KlüverHelmholtz Centre for Environmental Research - UFZ, Chemicals in the Environment Research Section, Leipzig, Germany.
Anja Knoll-GellidaUniversité de Bordeaux, Institut National de la Santé et de la Recherche Médicale (INSERM), Maladies Rares: Génétique et Métabolisme (MRGM), Pessac, France.
Britta A KühneUniversity of Veterinary Medicine Hannover, Foundation, Institute for Food Quality and Food Safety, Hannover, Germany.
Marcel LeistUniversity of Konstanz, In Vitro Toxicology and Biomedicine/CAAT-Europe, Konstanz, Germany.
Malene LislienNorwegian Institute of Public Health - NIPH, Department of Chemical Toxicology, Oslo, Norway.
Jan L LycheNorwegian University of Life Sciences (NMBU), Faculty of Veterinary Medicine, Ås, Norway.
Ferenc MüllerUniversity of Birmingham, Centre for Environmental Research and Justice, Birmingham, UK.
John K ColbourneUniversity of Birmingham, Centre for Environmental Research and Justice, Birmingham, UK.
Winfried NeuhausAIT Austrian Institute of Technology GmbH, Competence Unit Molecular Diagnostics, Center Health and Bioresources, Vienna, Austria.
Giorgia PalloccaUniversity of Konstanz, In Vitro Toxicology and Biomedicine/CAAT-Europe, Konstanz, Germany.
Bettina SeegerUniversity of Veterinary Medicine Hannover, Foundation, Institute for Food Quality and Food Safety, Hannover, Germany.
Ilka ScharkinIUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
Stefan ScholzHelmholtz Centre for Environmental Research - UFZ, Chemicals in the Environment Research Section, Leipzig, Germany.
Ola SpjuthUppsala University and Science for Life Laboratory, Department of Pharmaceutical Biosciences, Uppsala, Sweden.
Monica Torres-RuizInstituto de Salud Carlos III (ISCIII), Centro Nacional de Sanidad Ambiental (CNSA), Environmental Toxicology Unit, Majadahonda, Spain.
Kristina BartmannIUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the European regulatory context, rodent

Indexed as

adult neurotoxicity (ANT)applicability domaindevelopmental neurotoxicity (DNT)DNT-IVBnew approach method (NAM)zebrafish

Identifiers

PMID38742231
PMCPMC11089904

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.