Evidence map›Paper›PMID 38742194›Full record

ArticleFrontiers in endocrinology2024

Estradiol improves behavior in FAD transgenic mice that express

Deebika Balu, Ana C Valencia-Olvera, Ashwini Deshpande, Saharsh Narayanam, Sravya Konasani, Shreya Pattisapu, Jason M York, Gregory R J Thatcher, Mary Jo LaDu, Leon M Tai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. One size does not fit all: how type of menopause and hormone therapy matters for brain health.The British journal of psychiatry : the journal of mental science · 2025
    Review
  3. The novel estrogen receptor beta agonist EGX358 andFrontiers in aging neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Deebika BaluDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, United States.
Ana C Valencia-OlveraDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, United States.
Ashwini DeshpandeDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, United States.
Saharsh NarayanamDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, United States.
Sravya KonasaniDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, United States.
Shreya PattisapuDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, United States.
Jason M YorkDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, United States.
Gregory R J ThatcherSkaggs Pharmaceutical Sciences Center, University of Arizona, Tucson, AZ, United States.
Mary Jo LaDuDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, United States.
Leon M TaiDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, United States.

Funding

Deciphering molecular mechanisms that underlie brain endothelial cell dysfunction with APOE4R01AG061114 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Leon Maing Tai · 2019 to 2026
$4.7M
R01 Estrogen therapy and APOE4 risk in Alzheimer's tested in female EFAD miceR01AG057008 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LADU, MARY JO, THATCHER, GREGORY R. J · 2017 to 2020
$2.5M
ETHNOGRAPHY OF DYING IN A LONG TERM CARE FACILITYR01AG015806 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI KAYSER-JONES, JEANIE · 1998 to 2002
$1.3M
Potential ApoE Isoform-Specific Detrimental Effects of RXR Agonists in Alzheimer'R21AG044682 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LADU, MARY JO, THATCHER, GREGORY R. J · 2014 to 2015
$423k
NIA NIH HHS R01 AG015806NIA NIH HHS R01 AG057008NIA NIH HHS R01 AG061114NIA NIH HHS R21 AG044682
6 · The paper itself

Abstract

Increasing evidence suggests that female individuals have a higher Alzheimer's disease (AD) risk associated with post-menopausal loss of circulating estradiol (E

Indexed as

Apolipoprotein E3Apolipoprotein E4EstradiolOvariectomyAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBehavior, AnimalDisease Models, AnimalFemaleHumansMiceMice, TransgenicAmyloid beta-PeptidesApolipoprotein E3Apolipoprotein E4EstradiolAlzheimer’s diseaseamyloid-betaApoE4female risktransgenic mice

Identifiers

PMID38742194
PMCPMC11089251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.