Evidence map›Paper›PMID 38742164›Full record

ArticleInternational journal of MCH and AIDS2024

Impact of Maternal Viral Suppression on Growth Patterns for HIV-Exposed Uninfected Infants in Kenya.

Katherine Magerko, John Humphrey, Julia Songok, Beverly Musick, Joy Marsha Alera, Bett Kipchumba, Wycliffe Kosgei, Winfred Mwangi, Kara Yang, Ziyi Wools-Kaloustian and 1 more

Abstract read
In one paragraph

Article in International journal of MCH and AIDS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Katherine MagerkoDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States.
John HumphreyDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Julia SongokDepartment of Pediatrics, Moi University College of Health Sciences, School of Medicine, Eldoret, Kenya.
Beverly MusickDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Joy Marsha AleraDepartment of Academic Model Providing Access to Healthcare, Moi Teaching and Referral Hospital, Eldoret, Kenya.
Bett KipchumbaDepartment of Reproductive Health, Moi Teaching and Referral Hospital, Eldoret, Kenya.
Wycliffe KosgeiDepartment of Reproductive Health, Moi Teaching and Referral Hospital, Eldoret, Kenya.
Winfred MwangiDepartment of Reproductive Health, Moi Teaching and Referral Hospital, Eldoret, Kenya.
Kara YangDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Ziyi Wools-KaloustianDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Megan S McHenryDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States.

Funding

East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional ConsortiumU01AI069911 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Leslie Anne Enane, AGGREY SEMWENDERO SEMEERE · 2006 to 2026
$57.7M
NIAID NIH HHS U01 AI069911
6 · The paper itself

Abstract

Background and Objective: Children born to mothers living with human immunodeficiency virus (HIV) are at risk for poor health outcomes but data characterizing these associations are limited. Our objective was to determine the impact of maternal viral suppression on growth patterns and malnutrition for infants who are HIV-exposed but uninfected (HEU). Methods: We conducted a retrospective cohort analysis of clinical data for infants who were HEU and their mothers (September 2015 - March 2019) in Kenya. Infants were stratified based on maternal viral suppression status (≥ or <1000 copies/mL); Results: Among 674 infants who were HEU, 48.7% were male and 85.0% had mothers who were virally suppressed. The median age at first and last clinic visits was 1.5 and 16.4 months, respectively. WFA and HFA z-scores over time differed by sex, and WFA and HFA differed based on maternal viral suppression ( Conclusion and Global Health Implications: Maternal viral suppression status was not associated with increased odds of more severe malnutrition indicators in children who were HEU. However, overall growth patterns over time, measured by z-scores of growth indicators, did differ based on maternal viral suppression status, and to a lesser degree, by gender.

Indexed as

KenyaKey and Vulnerable PopulationsLow- and Middle-Income CountriesViral Load MonitoringViral Suppression

Identifiers

PMID38742164
PMCPMC11090584

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.