Evidence map›Paper›PMID 38741447›Full record

Observational studyAnaesthesiology intensive therapy2024

Nutritional responsiveness affects novel neutrophil parameters and reduces in-hospital mortality and costs in elective cancer oesophagectomy - a single centre, prospective, observational study.

Paweł Kutnik, Michał Borys, Kamil Nurczyk, Weronika Domerecka, Jacek Dziedzic, Grzegorz Buszewicz, Grzegorz Teresiński, Helena Donica, Paweł Piwowarczyk, Mirosław Czuczwar

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Anaesthesiology intensive therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Paweł Kutnik2nd Department of Anaesthesiology and Intensive Care, Medical University of Lublin, Lublin, Poland.
Michał Borys2nd Department of Anaesthesiology and Intensive Care, Medical University of Lublin, Lublin, Poland.
Kamil Nurczyk2nd Department of General and Gastrointestinal Surgery, and Surgical Oncology of the Alimentary Tract, Medical University of Lublin, Lublin, Poland.
Weronika DomereckaDepartment of Laboratory Diagnostics, University Teaching Hospital No 1 in Lublin, Poland.
Jacek Dziedzic2nd Department of General and Gastrointestinal Surgery, and Surgical Oncology of the Alimentary Tract, Medical University of Lublin, Lublin, Poland.
Grzegorz BuszewiczLaboratory of Forensic Toxicology, Department of Forensic Medicine, Medical University of Lublin, Lublin, Poland.
Grzegorz TeresińskiDepartment of Forensic Medicine, Medical University of Lublin, Lublin, Poland.
Helena DonicaDepartment of Biochemical Diagnostics, Chair of Laboratory Diagnostics, Medical University of Lublin, Lublin, Poland.
Paweł Piwowarczyk2nd Department of Anaesthesiology and Intensive Care, Medical University of Lublin, Lublin, Poland.
Mirosław Czuczwar2nd Department of Anaesthesiology and Intensive Care, Medical University of Lublin, Lublin, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMalnutrition in surgical patients remains a common issue affecting the perioperative period. Oesophageal cancer is a disease associated with one of the highest malnutrition rates. Assessment of patient nutritional status remains a challenge due to limited validated tools. Novel parameters to identify malnourished patients and the effectiveness of preoperative nutritional intervention might improve treatment results in the perioperative period. MATERIAL AND

methodsThis was a prospective, observational, single-centre study of patients scheduled for elective oesophagectomy. The primary aim of this study was to establish the correlation between neutrophil reactivity intensity (NEUT-RI) and neutrophil granularity intensity (NEUT-GI) and patients' nutritional status. We divided patients into nutritional responders (R group) and nutritional non-responders (NR group) defined as regaining at least 25% of the maximum preoperative body weight loss during the preoperative period.

resultsThe R group had significantly shorter intensive care unit (ICU) stays: 5.5 (4-8) vs. 13 (7-31) days ( P = 0.01). It resulted in a lower cost of ICU stays in the R group: 4775.2 (3938.9-7640.7) vs. 12255.8 (7787.6-49108.7) euro in the NR group ( P = 0.01). Between the R group and the NR group, we observed statistically significant differences in both preoperative NEUT-RI (48.6 vs. 53.4, P = 0.03) and NEUT-GI (154.6 vs. 159.3, P = 0.02). Apart from the T grade, the only preoperative factor associated with reduced mortality was the nutritional responsiveness: 11.1% vs. 71.4% ( P = 0.008).

conclusionsPreoperative nutritional responsiveness affects neutrophil intensity indexes and reduces in-hospital mortality and costs associated with hospital stay. Further research is required to determine the correlation between novel neutrophil parameters and patients' nutritional status.

Indexed as

Elective Surgical ProceduresEsophageal NeoplasmsEsophagectomyHospital MortalityNeutrophilsNutritional StatusAgedFemaleHumansIntensive Care UnitsLength of StayMaleMalnutritionMiddle AgedProspective StudiesGLIMmalnutritionNEUT-GINEUT-RIoesophageal canceroesophagectomyoesophago-gastric junction cancerperioperative nutrition

Identifiers

PMID38741447
PMCPMC11022637

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.