ArticleAnimal models and experimental medicine2024
Age-related changes in behavior profile in male offspring of rats treated with poly I:C-induced maternal immune activation in early gestation.
Article in Animal models and experimental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Adolescent anodal tDCS ameliorates behavioral deficits and microglial abnormalities in a maternal immune activation mouse model of schizophrenia.Psychopharmacology · 2026Article
- A potential strategy for improving offspring behavior in maternal immune activation: Amantadine-mediated suppression of neuroinflammation.Animal models and experimental medicine · 2025Article
- Poly (I:C)-induced maternal immune activation generates impairment of reversal learning performance in offspring.Journal of neurochemistry · 2025Article
- Age-related changes in behavior profile in male offspring of rats treated with poly I:C-induced maternal immune activation in early gestation.Animal models and experimental medicine · 2024Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundAutism and schizophrenia are environmental risk factors associated with prenatal viral infection during pregnancy. It is still unclear whether behavior phenotypes change at different developmental stages in offspring following the activation of the maternal immune system.
methodsSprague-Dawley rats received a single caudal vein injection of 10 mg/kg polyinosinic:polycytidylic acid (poly I:C) on gestational day 9 and the offspring were comprehensively tested for behaviors in adolescence and adulthood.
resultsMaternal serum levels of interleukin (IL)-6, IL-1β and tumor necrosis factor-α were elevated in poly I:C-treated dams. The offspring of maternal poly I:C-induced rats showed increased anxiety, impaired social approach, and progressive impaired cognitive and sensorimotor gating function.
conclusionMaternal immune activation led to developmental specificity behavioral impairment in offspring.
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