Evidence map›Paper›PMID 38741267›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2024

Switching off: disruptive TMS reveals distinct contributions of the posterior middle temporal gyrus and angular gyrus to bilingual speech production.

Polina Timofeeva, Alessandra Finisguerra, Giulia D'Argenio, Adolfo M García, Manuel Carreiras, Ileana Quiñones, Cosimo Urgesi, Lucia Amoruso

Abstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Polina TimofeevaBCBL, Basque Center on Cognition, Brain, and Language (BCBL), Paseo Mikeletegi 69, 2nd floor, 20009 San Sebastian, Spain.
Alessandra FinisguerraScientific Institute, IRCCS E. Medea, Via Cialdini 29, 33037, Pasian di Prato, UD, Italy.
Giulia D'ArgenioLaboratory of Cognitive Neuroscience, Department of Languages and Literatures, Communication, Education and Society, University of Udine, Via Margreth 3, 33100, Udine, Italy.
Adolfo M GarcíaCognitive Neuroscience Center (CNC), University of San Andres, Vito Dumas 284, B1644 BID, Buenos Aires, Argentina.
Manuel CarreirasBCBL, Basque Center on Cognition, Brain, and Language (BCBL), Paseo Mikeletegi 69, 2nd floor, 20009 San Sebastian, Spain.
Ileana QuiñonesIkerbasque, Basque Foundation for Science, Plaza Euskadi 5, 48009, Bilbao, Spain.
Cosimo UrgesiScientific Institute, IRCCS E. Medea, Via Cialdini 29, 33037, Pasian di Prato, UD, Italy.
Lucia AmorusoBCBL, Basque Center on Cognition, Brain, and Language (BCBL), Paseo Mikeletegi 69, 2nd floor, 20009 San Sebastian, Spain.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2M
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1M
Alzheimer's Association SG-20-725707FIC NIH HHSNIA NIH HHS P01 AG019724NIA NIH HHS R01 AG057234NIA NIH HHS R01AG057234NIA NIH HHS R01 AG075775NIH HHS
6 · The paper itself

Abstract

The role of the left temporoparietal cortex in speech production has been extensively studied during native language processing, proving crucial in controlled lexico-semantic retrieval under varying cognitive demands. Yet, its role in bilinguals, fluent in both native and second languages, remains poorly understood. Here, we employed continuous theta burst stimulation to disrupt neural activity in the left posterior middle-temporal gyrus (pMTG) and angular gyrus (AG) while Italian-Friulian bilinguals performed a cued picture-naming task. The task involved between-language (naming objects in Italian or Friulian) and within-language blocks (naming objects ["knife"] or associated actions ["cut"] in a single language) in which participants could either maintain (non-switch) or change (switch) instructions based on cues. During within-language blocks, cTBS over the pMTG entailed faster naming for high-demanding switch trials, while cTBS to the AG elicited slower latencies in low-demanding non-switch trials. No cTBS effects were observed in the between-language block. Our findings suggest a causal involvement of the left pMTG and AG in lexico-semantic processing across languages, with distinct contributions to controlled vs. "automatic" retrieval, respectively. However, they do not support the existence of shared control mechanisms within and between language(s) production. Altogether, these results inform neurobiological models of semantic control in bilinguals.

Indexed as

MultilingualismParietal LobeSpeechTemporal LobeTranscranial Magnetic StimulationAdultCuesFemaleHumansMaleYoung Adultangular gyrusbilingualismcontinuous theta burst stimulationposterior middle temporal gyrusspeech production

Identifiers

PMID38741267
PMCPMC11090997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.