ArticleCritical care (London, England)2024
Organ donation after extracorporeal cardiopulmonary resuscitation: a nationwide retrospective cohort study.
Article in Critical care (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Temporal changes in clinical practices for patients considered clinically brain dead: a single-center cohort study.Journal of intensive care · 2026Article
- Associations of Vasopressin and Corticosteroid Therapy with Organ Yield in Brain-Dead Donors: A Multicenter Cohort Study in Japan.Neurocritical care · 2026Article
- Utilization and outcomes of organs from ECMO-supported brain-dead donors: two-center experience.Journal of intensive care · 2026Article
- Sequence and timing of organ donation discussions in brain-dead donors: a subanalysis of the J-RESPECT study.Journal of intensive care · 2026Article
- Organ donation after ECPR: ethical challenges and clinical implications.Critical care (London, England) · 2026Review
- Cost effectiveness of pre-hospital extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest - An analysis of the PRECARE study.Resuscitation plus · 2026Article
- The Evolving Role of Extracorporeal In Situ Perfusion Technology in Organ Donor Recovery with Donation After Circulatory Determination of Death Organ Donors.Medicina (Kaunas, Lithuania) · 2025Review
- [Special aspects of patients with va-ECMO on the way to organ donation].Die Anaesthesiologie · 2025Review
- Association of emergency intensive care unit occupancy due to brain-dead organ donors with ambulance diversion.Scientific reports · 2025Article
- Organ donation from extracorporeal membrane oxygenation and ventricular assist devices in Victoria, Australia: Characteristics and trends.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Extracorporeal Cardiopulmonary Resuscitation-Where Do We Currently Stand?Biomedicines · 2025Review
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Authors and funding
7 authors.
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Abstract
backgroundLimited data are available on organ donation practices and recipient outcomes, particularly when comparing donors who experienced cardiac arrest and received extracorporeal cardiopulmonary resuscitation (ECPR) followed by veno-arterial extracorporeal membrane oxygenation (ECMO) decannulation, versus those who experienced cardiac arrest without receiving ECPR. This study aims to explore organ donation practices and outcomes post-ECPR to enhance our understanding of the donation potential after cardiac arrest.
methodsWe conducted a nationwide retrospective cohort study using data from the Japan Organ Transplant Network database, covering all deceased organ donors between July 17, 2010, and August 31, 2022. We included donors who experienced at least one episode of cardiac arrest. During the study period, patients undergoing ECMO treatment were not eligible for a legal diagnosis of brain death. We compared the timeframes associated with each donor's management and the long-term graft outcomes of recipients between ECPR and non-ECPR groups.
resultsAmong 370 brain death donors with an episode of cardiac arrest, 26 (7.0%) received ECPR and 344 (93.0%) did not; the majority were due to out-of-hospital cardiac arrests. The median duration of veno-arterial ECMO support after ECPR was 3 days. Patients in the ECPR group had significantly longer intervals from admission to organ procurement compared to those not receiving ECPR (13 vs. 9 days, P = 0.005). Lung graft survival rates were significantly lower in the ECPR group (log-rank test P = 0.009), with no significant differences in other organ graft survival rates. Of 160 circulatory death donors with an episode of cardiac arrest, 27 (16.9%) received ECPR and 133 (83.1%) did not. Time intervals from admission to organ procurement following circulatory death and graft survival showed no significant differences between ECPR and non-ECPR groups. The number of organs donated was similar between the ECPR and non-ECPR groups, regardless of brain or circulatory death.
conclusionsThis nationwide study reveals that lung graft survival was lower in recipients from ECPR-treated donors, highlighting the need for targeted research and protocol adjustments in post-ECPR organ donation.
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