Evidence map›Paper›PMID 38741174›Full record

ArticleTrials2024

Targeting strategies for balanced energy and protein (BEP) supplementation in pregnancy: study protocol for the TARGET-BEP cluster-randomized controlled trial in rural Bangladesh.

Eleonor Zavala, Diwakar Mohan, Hasmot Ali, Towfida J Siddiqua, Rezwanul Haque, Kaniz Ayesha, Khalid Bin Ahsan, Hasan Mahmud Sujan, Nazrana Khaled, Atiya Rahman and 9 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05576207 (Balanced Energy and Protein), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05576207 nacompletednot on this map

Balanced Energy and Protein (BEP) Supplementation Research in Bangladesh (JiVitA-BEP IR)

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2022 to 2025Enrolled3,390ConditionsFetal Growth Retardation, Low Birth Weight, Preterm Birth, Gestational Weight GainArmsBalanced energy and protein supplement for pregnant women, Multiple Micronutrient Supplement for pregnant women
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Eleonor ZavalaDepartment of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Diwakar MohanDepartment of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Hasmot AliThe JiVitA Project, Rangpur, Bangladesh.
Towfida J SiddiquaThe JiVitA Project, Rangpur, Bangladesh.
Rezwanul HaqueThe JiVitA Project, Rangpur, Bangladesh.
Kaniz AyeshaThe JiVitA Project, Rangpur, Bangladesh.
Khalid Bin AhsanThe JiVitA Project, Rangpur, Bangladesh.
Hasan Mahmud SujanThe JiVitA Project, Rangpur, Bangladesh.
Nazrana KhaledJames P. Grant School of Public Health, BRAC University, Dhaka, Bangladesh.
Atiya RahmanJames P. Grant School of Public Health, BRAC University, Dhaka, Bangladesh.
Barnali ChakrabortyDepartment of Public Health, North South University, Dhaka, Bangladesh.
Brian DyerDepartment of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Lee S F WuDepartment of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Anna KalbarczykDepartment of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Daniel J ErchickDepartment of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Andrew L Thorne-LymanDepartment of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Alison TumilowiczThe Bill & Melinda Gates Foundation, Seattle, USA.
Kaosar AfsanaJames P. Grant School of Public Health, BRAC University, Dhaka, Bangladesh.
Parul ChristianDepartment of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA. pchrist1@jhu.edu.

Funding

Bill & Melinda Gates Foundation INV-033381
6 · The paper itself

Abstract

backgroundThe World Health Organization (WHO) recommends balanced energy and protein (BEP) supplementation be provided to all pregnant women living in undernourished populations, usually defined as having a prevalence > 20% of underweight women, to reduce the risk of stillbirths and small-for-gestational-age neonates. Few geographies meet this threshold, however, and a large proportion of undernourished women and those with inadequate gestational weight gain could miss benefiting from BEP. This study compares the effectiveness of individual targeting approaches for supplementation with micronutrient-fortified BEP vs. multiple micronutrient supplements (MMS) alone as control in pregnancy in improving birth outcomes.

methodsThe TARGET-BEP study is a four-arm, cluster-randomized controlled trial conducted in rural northwestern Bangladesh. Eligible participants are married women aged 15-35 years old identified early in pregnancy using a community-wide, monthly, urine-test-based pregnancy detection system. Beginning at 12-14 weeks of gestation, women in the study area comprising 240 predefined sectors are randomly assigned to one of four intervention arms, with sector serving as the unit of randomization. The interventions involving daily supplementation through end of pregnancy are as follows: (1) MMS (control); (2) BEP; (3) targeted BEP for those with pre-pregnancy body mass index (BMI) < 18.5 kg/m DISCUSSION: This study will assess the effectiveness of targeted balanced energy and protein supplementation to improve birth outcomes among pregnant women in rural Bangladesh and similar settings.

trial registrationClinicalTrials.gov NCT05576207. Registered on October 5th, 2022.

Indexed as

Dietary ProteinsDietary SupplementsGestational Weight GainRandomized Controlled Trials as TopicAdolescentAdultBangladeshBirth WeightEnergy IntakeFemaleGestational AgeHumansInfant, NewbornMaternal Nutritional Physiological PhenomenaMicronutrientsNutritional StatusDietary ProteinsMicronutrientsBalanced energy and protein supplementationBangladeshBirth outcomesGestational weight gainLow birth weightMaternal nutritionRandomized trialSmall for gestational age

Identifiers

PMID38741174
PMCPMC11089740

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.