Evidence map›Paper›PMID 38741109›Full record

ArticleBMC veterinary research2024

Assessment of tumor hypoxia in spontaneous canine tumors after treatment with OMX, a novel H-NOX oxygen carrier, with [

Sangkyung Choen, Michael S Kent, F Alexandra Loucks, Jonathan A Winger, Allison L Zwingenberger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sangkyung ChoenDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, 1 Shields Ave, 2112 Tupper Hall, Davis, CA, 95616, USA.
Michael S KentDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, 1 Shields Ave, 2112 Tupper Hall, Davis, CA, 95616, USA.
F Alexandra LoucksOmniox, Inc., San Francisco, CA, USA.
Jonathan A WingerOmniox, Inc., San Francisco, CA, USA.
Allison L ZwingenbergerDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, 1 Shields Ave, 2112 Tupper Hall, Davis, CA, 95616, USA. azwingen@ucdavis.edu.

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura Marcu · 2002 to 2026
$84.9M
NCI NIH HHS NCI P30CA093373NCI NIH HHS P30 CA093373NIH HHS R01CA20472
6 · The paper itself

Abstract

backgroundHypoxia is a detrimental factor in solid tumors, leading to aggressiveness and therapy resistance. OMX, a tunable oxygen carrier from the heme nitric oxide/oxygen-binding (H-NOX) protein family, has the potential to reduce tumor hypoxia. [

resultsThirteen canine patients with various tumors (n = 14) were randomly divided into blocks of two, with the treatment groups alternating between receiving intratumoral (IT) OMX injection (OMX IT group) and intravenous (IV) OMX injection (OMX IV group). Tumors were regarded as hypoxic if maximum tumor-to-muscle ratio (TMR

conclusions[

Indexed as

Dog DiseasesMisonidazoleNeoplasmsPositron Emission Tomography Computed TomographyTumor HypoxiaAnimalsCoordination ComplexesDogsFemaleMaleThiosemicarbazonesCoordination Complexescopper (II) diacetyl-di(N(4)-methylthiosemicarbazone)fluoromisonidazoleMisonidazoleThiosemicarbazones[18F]Fluoromisonidazole ([18F]FMISO)Canine tumorsComputed tomography (CT)H-NOX proteinNon-invasive imagingOxygen carrierPositron emission tomography (PET)Therapy resistanceTumor hypoxia

Identifiers

PMID38741109
PMCPMC11089780

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.