Evidence map›Paper›PMID 38741104›Full record

ArticleDiagnostic pathology2024

Proposed diagnostic and prognostic markers of primary malignant hepatic vascular neoplasms.

Youngeun Yoo, Jinho Shin, Eunsung Jun, Eun-Young Koh, Hwa Jeong Shin, Hyo Jeong Kang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Youngeun Yoo *Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Jinho Shin *Department of Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Eunsung JunDepartment of Convergence Medicine, Asan Medical Center, Asan Institute for Life Sciences, University of Ulsan College of Medicine Seoul, Seoul, Republic of Korea. eunsungjun@amc.seoul.kr.
Eun-Young KohDepartment of Convergence Medicine, Asan Medical Center, Asan Institute for Life Sciences, University of Ulsan College of Medicine Seoul, Seoul, Republic of Korea.
Hwa Jeong ShinDepartment of Research Support Team, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Hyo Jeong KangDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea. d100478hjk@gmail.com.

Funding

Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea 2022IP0032National Research Foundation of Korea 2020R1F1A1074056NCIRD CDC HHS U01 IP000032
6 · The paper itself

Abstract

introductionPrimary malignant hepatic vascular tumors with various malignant potentials include epithelioid hemangioendothelioma (EHE) and angiosarcoma (AS), which may overlap pathologically. This study aimed to compare the pathological findings of hepatic EHE with those of AS, in association with patient outcomes.

methodsFifty-nine histologically confirmed patients with 34 EHE and 25 AS were admitted to a tertiary hospital from 2003 to 2020. Their EHE and AS pathological features were compared. Immunohistochemistry for CD31, ERG, CAMTA-1, TFE3, P53, and Ki-67 labeling was performed on paraffin-embedded blocks. Markers, along with histological findings, were analyzed for the purposes of diagnostic and prognostic significance by multivariate analysis.

resultsCAMTA-1 was 91.2% positive in EHE, but negative in AS (p = < 0.001). AS was significantly correlated to an aberrant p53 expression, high Ki-67 labeling, and high mitotic activity, compared to EHE (all, p = < 0.001). EHE can be classified as low grade (LG) and high grade (HG) using the prognostic values of mitotic activity and ki-67 labeling (sensitivity = 1, specificity = 1). Low grade-EHE showed significantly better overall survival than high grade-EHE (p = 0.020).

conclusionsImmunohistochemistry for CAMTA-1, P53, and Ki-67 labeling may help distinguish EHE and AS in histologically ambiguous cases, especially small biopsied tissue. Moreover, the combination of mitotic activity and Ki-67 labeling can be a prognostic factor for EHE with various clinical features.

Indexed as

Biomarkers, TumorHemangioendothelioma, EpithelioidHemangiosarcomaLiver NeoplasmsAdultAgedCalcium-Binding ProteinsFemaleHumansImmunohistochemistryKi-67 AntigenMaleMiddle AgedPrognosisTrans-ActivatorsYoung AdultBiomarkers, TumorCalcium-Binding ProteinsCAMTA1 protein, humanKi-67 AntigenTrans-ActivatorsAngiosarcomaDiagnosisEpithelioid hemangioendotheliomaLiverMalignancyVascular neoplasm

Identifiers

PMID38741104
PMCPMC11089664

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.